OBJECTIVE: To describe the incidence of HPV in diffuse high grade pre-cancerous lesions of the larynx. METHODS: Patient charts were searched for those who presented between October 2008 and June 2009 with diffuse vocal fold leukoplakia. Biopsy proven laryngeal lesions with high grade dysplasia or carcinoma-in-situ (CIS) were examined for patient characteristics and presence of high-risk type HPV detected by in situ hybridization technique. RESULTS: Fifteen patients with precancerous lesions were identified. Average age was 63 years and 13 were male. One lesion was identified as positive for high-risk HPV, all other lesions were negative. At current follow up, no patient has demonstrated progression to invasive carcinoma. CONCLUSION: HPV may not play a role in non-progressing diffuse high-grade lesions of the larynx.
OBJECTIVE: To describe the incidence of HPV in diffuse high grade pre-cancerous lesions of the larynx. METHODS:Patient charts were searched for those who presented between October 2008 and June 2009 with diffuse vocal fold leukoplakia. Biopsy proven laryngeal lesions with high grade dysplasia or carcinoma-in-situ (CIS) were examined for patient characteristics and presence of high-risk type HPV detected by in situ hybridization technique. RESULTS: Fifteen patients with precancerous lesions were identified. Average age was 63 years and 13 were male. One lesion was identified as positive for high-risk HPV, all other lesions were negative. At current follow up, no patient has demonstrated progression to invasive carcinoma. CONCLUSION: HPV may not play a role in non-progressing diffuse high-grade lesions of the larynx.
Authors: Edward Odell; Hans Edmund Eckel; Ricard Simo; Miquel Quer; Vinidh Paleri; Jens Peter Klussmann; Marc Remacle; Elisabeth Sjögren; Cesare Piazza Journal: Eur Arch Otorhinolaryngol Date: 2020-10-13 Impact factor: 2.503