| Literature DB >> 21224206 |
Yuemin Liu1, August A Gallo, Rakesh K Bajpai, Andrei Chistoserdov, Andrew Nelson, Leah Segura, Wu Xu.
Abstract
To broaden our knowledge on the diversity of glycerol dehydratases, comprehensive sequence and molecular modelling analyses of these enzymes were performed. Our sequence analysis showed that B₁₂-dependent and B₁₂-independent glycerol dehydratases are not related, suggesting that they evolved from different ancestors. Second, our study demonstrated that a gene fusion event occurred between α and β subunits of B₁₂-dependent glycerol dehydratases in several bacteria during enzyme evolution. In addition, our sequence and molecular modelling analyses revealed more B₁₂-independent glycerol dehydratases including hypothetical proteins. Furthermore, we found that some microorganisms contain both B₁₂-dependent and B₁₂-independent glycerol dehydratases in their genomes.Entities:
Mesh：
Substances：
Year: 2010 PMID： 21224206 DOI： 10.1504/IJBRA.2010.037988
Source DB: PubMed Journal: Int J Bioinform Res Appl ISSN： 1744-5485