Literature DB >> 2122331

Long-term changes of synaptic transmission induced by arachidonic acid in the CA1 subfield of the rat hippocampus.

C Drapeau1, L Pellerin, L S Wolfe, M Avoli.   

Abstract

The effects induced by arachidonic acid upon excitatory synaptic transmission were investigated in the CA1 subfield of rat hippocampal slices. Perfusion with medium containing 50 microM of arachidonic acid induced in 12 of 19 experiments a long-lasting potentiation of the stratum radiatum-induced responses recorded in the cell body and in the apical dendritic layers. In 5 of 19 experiments, arachidonic acid evoked a depression of the same responses. Both effects were antagonized by nordihydroguaiaretic acid which is an inhibitor of lipoxygenase enzymes. These results demonstrate that one or more than one of the arachidonic acid metabolites of the lipoxygenase pathways might be involved in the long-term modulation of synaptic transmission in the hippocampus.

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Year:  1990        PMID： 2122331     DOI： 10.1016/0304-3940(90)90470-t

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  11 in total

1.  Arachidonic acid inhibits transient potassium currents and broadens action potentials during electrographic seizures in hippocampal pyramidal and inhibitory interneurons.

Authors:  S Keros; C J McBain
Journal:  J Neurosci       Date:  1997-05-15       Impact factor: 6.167

2.  A postsynaptic transient K(+) current modulated by arachidonic acid regulates synaptic integration and threshold for LTP induction in hippocampal pyramidal cells.

Authors:  Geert M J Ramakers; Johan F Storm
Journal:  Proc Natl Acad Sci U S A       Date:  2002-07-11       Impact factor: 11.205

Review 3.  The role of secretory phospholipase A₂ in the central nervous system and neurological diseases.

Authors:  Tatsurou Yagami; Yasuhiro Yamamoto; Hiromi Koma
Journal:  Mol Neurobiol       Date:  2013-10-10       Impact factor: 5.590

4.  Kinetic modulation of Kv4-mediated A-current by arachidonic acid is dependent on potassium channel interacting proteins.

Authors:  M H Holmqvist; J Cao; M H Knoppers; M E Jurman; P S Distefano; K J Rhodes; Y Xie; W F An
Journal:  J Neurosci       Date:  2001-06-15       Impact factor: 6.167

5.  Release of arachidonic acid by NMDA-receptor activation in the rat hippocampus.

Authors:  L Pellerin; L S Wolfe
Journal:  Neurochem Res       Date:  1991-09       Impact factor: 3.996

6.  Tests of the roles of two diffusible substances in long-term potentiation: evidence for nitric oxide as a possible early retrograde messenger.

Authors:  T J O'Dell; R D Hawkins; E R Kandel; O Arancio
Journal:  Proc Natl Acad Sci U S A       Date:  1991-12-15       Impact factor: 11.205

7.  Docosahexaenoic acid improves long-term potentiation attenuated by phospholipase A(2) inhibitor in rat hippocampal slices.

Authors:  S Fujita; Y Ikegaya; M Nishikawa; N Nishiyama; N Matsuki
Journal:  Br J Pharmacol       Date:  2001-04       Impact factor: 8.739

Review 8.  Activation by GABAb, reduction of the intracellular concentration of Ca++, and inhibition of protein kinases are possible mechanisms of the long-term posttetanic modification of the efficiency of inhibitory transmission in the new cortex.

Authors:  I G Sil'kis
Journal:  Neurosci Behav Physiol       Date:  1996 Jan-Feb

9.  12-lipoxygenase metabolites of arachidonic acid mediate metabotropic glutamate receptor-dependent long-term depression at hippocampal CA3-CA1 synapses.

Authors:  Steven J Feinmark; Roxana Begum; Evgeny Tsvetkov; Ivan Goussakov; Colin D Funk; Steven A Siegelbaum; Vadim Y Bolshakov
Journal:  J Neurosci       Date:  2003-12-10       Impact factor: 6.167

Review 10.  Maintenance of synaptic stability requires calcium-independent phospholipase A₂ activity.

Authors:  Julie Allyson; Xiaoning Bi; Michel Baudry; Guy Massicotte
Journal:  Neural Plast       Date:  2012-05-20       Impact factor: 3.599
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