Literature DB >> 2122249

In vitro biosynthesis and membrane translocation of the serine rich protein of Plasmodium falciparum.

K Ragge1, H H Arnold, M Tümmler, B Knapp, E Hundt, K Lingelbach.   

Abstract

The serine-rich protein (SERP) of Plasmodium falciparum is found within the parasitophorous vacuole. Exons 1 and 2 of the SERP gene were combined to a continuous open reading frame and expressed in a cell free translation/translocation system to study translocation of the protein across membranes. The protein was found to be translocated co-translationally across canine pancreatic microsomes. This process required the presence of the signal recognition particle, and it was accompanied by cleavage of a signal peptide. We conclude that the authentic SERP is exported from the parasite cell via the endoplasmic reticulum.

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Year:  1990        PMID： 2122249     DOI： 10.1016/0166-6851(90)90116-4

Source DB:  PubMed          Journal:  Mol Biochem Parasitol        ISSN： 0166-6851            Impact factor:   1.759


  12 in total

Review 1.  Structure and possible function of Plasmodium falciparum proteins exported to the erythrocyte membrane.

Authors:  B Knapp; E Hundt; K R Lingelbach
Journal:  Parasitol Res       Date:  1991       Impact factor: 2.289

2.  In vitro biosynthesis and in vivo processing of the major microneme antigen of Sarcocystis muris cyst merozoites.

Authors:  H Klein; H Mehlhorn; W Rüger
Journal:  Parasitol Res       Date:  1996       Impact factor: 2.289

3.  The chaperonin TRiC forms an oligomeric complex in the malaria parasite cytosol.

Authors:  Natalie J Spillman; Josh R Beck; Suresh M Ganesan; Jacquin C Niles; Daniel E Goldberg
Journal:  Cell Microbiol       Date:  2017-01-24       Impact factor: 3.715

4.  Immunogenicity of the Plasmodium falciparum serine repeat antigen (p126) expressed by vaccinia virus.

Authors:  J A Tine; V Conseil; P Delplace; C De Taisne; D Camus; E Paoletti
Journal:  Infect Immun       Date:  1993-09       Impact factor: 3.441

5.  Inhibition of malaria parasite development by a cyclic peptide that targets the vital parasite protein SERA5.

Authors:  W Douglas Fairlie; Tim P Spurck; Joanne E McCoubrie; Paul R Gilson; Susanne K Miller; Geoffrey I McFadden; Robyn Malby; Brendan S Crabb; Anthony N Hodder
Journal:  Infect Immun       Date:  2008-06-30       Impact factor: 3.441

6.  Brefeldin A inhibits transport of the glycophorin-binding protein from Plasmodium falciparum into the host erythrocyte.

Authors:  J Benting; D Mattei; K Lingelbach
Journal:  Biochem J       Date:  1994-06-15       Impact factor: 3.857

7.  Genetic evidence strongly support an essential role for PfPV1 in intra-erythrocytic growth of P. falciparum.

Authors:  Trang Chu; Klaus Lingelbach; Jude M Przyborski
Journal:  PLoS One       Date:  2011-03-31       Impact factor: 3.240

8.  Plasmodium falciparum full life cycle and Plasmodium ovale liver stages in humanized mice.

Authors:  Valérie Soulard; Henriette Bosson-Vanga; Audrey Lorthiois; Clémentine Roucher; Jean-François Franetich; Gigliola Zanghi; Mallaury Bordessoulles; Maurel Tefit; Marc Thellier; Serban Morosan; Gilles Le Naour; Frédérique Capron; Hiroshi Suemizu; Georges Snounou; Alicia Moreno-Sabater; Dominique Mazier
Journal:  Nat Commun       Date:  2015-07-24       Impact factor: 14.919

9.  PTEX component HSP101 mediates export of diverse malaria effectors into host erythrocytes.

Authors:  Josh R Beck; Vasant Muralidharan; Anna Oksman; Daniel E Goldberg
Journal:  Nature       Date:  2014-07-16       Impact factor: 49.962

10.  Identification and localization of ERD2 in the malaria parasite Plasmodium falciparum: separation from sites of sphingomyelin synthesis and implications for organization of the Golgi.

Authors:  H G Elmendorf; K Haldar
Journal:  EMBO J       Date:  1993-12       Impact factor: 11.598
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