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Literature DB >> 21221420

Label-Free Receptor Assays.

Abstract

Label-free biosensors offer integrated, kinetic and multi-parametric measures of receptor biology and ligand pharmacology in whole cells. Being highly sensitive and pathway-unbiased, label-free receptor assays can be used to probe the systems cell biology including pleiotropic signaling of receptors, and to characterize the functional selectivity and phenotypic pharmacology of ligand molecules. These assays provide a new dimension for elucidating receptor biology and for facilitating drug discovery.

Entities: CellLine Chemical Disease Gene Species

Year: 2011 PMID： 21221420 PMCID： PMC3017374 DOI： 10.1016/j.ddtec.2010.05.001

Source DB: PubMed Journal: Drug Discov Today Technol ISSN： 1740-6749

53 in total

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Journal: Curr Opin Chem Biol Date: 1999-10 Impact factor: 8.822

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Authors: C Watson; G Chen; P Irving; J Way; W J Chen; T Kenakin
Journal: Mol Pharmacol Date: 2000-12 Impact factor: 4.436

Review 3. Four-dimensional organization of protein kinase signaling cascades: the roles of diffusion, endocytosis and molecular motors.

Authors: Boris N Kholodenko
Journal: J Exp Biol Date: 2003-06 Impact factor: 3.312

Review 4. Biochemical and pharmacological control of the multiplicity of coupling at G-protein-coupled receptors.

Authors: Emmanuel Hermans
Journal: Pharmacol Ther Date: 2003-07 Impact factor: 12.310

5. Kinetics of adhesion and spreading of animal cells.

Authors: J J Ramsden; S Y Li; J E Prenosil; E Heinzle
Journal: Biotechnol Bioeng Date: 1994-04-25 Impact factor: 4.530

Review 6. 7TM pharmacology measured by label-free: a holistic approach to cell signalling.

Authors: Magalie Rocheville; Jeff C Jerman
Journal: Curr Opin Pharmacol Date: 2009-08-09 Impact factor: 5.547

7. Cluster analysis and display of genome-wide expression patterns.

Authors: M B Eisen; P T Spellman; P O Brown; D Botstein
Journal: Proc Natl Acad Sci U S A Date: 1998-12-08 Impact factor: 11.205

8. Beta-arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors.

Authors: Mounia Azzi; Pascale G Charest; Stéphane Angers; Guy Rousseau; Trudy Kohout; Michel Bouvier; Graciela Piñeyro
Journal: Proc Natl Acad Sci U S A Date: 2003-09-17 Impact factor: 11.205

9. Label-free optical biosensor for ligand-directed functional selectivity acting on beta(2) adrenoceptor in living cells.

Authors: Ye Fang; Ann M Ferrie
Journal: FEBS Lett Date: 2008-01-31 Impact factor: 4.124

10. Duplexed label-free G protein--coupled receptor assays for high-throughput screening.

Authors: Elizabeth Tran
Journal: J Biomol Screen Date: 2008-11-21

23 in total

1. Dynamic mass redistribution assays decode surface influence on signaling of endogenous purinergic P2Y receptors.

Authors: Elizabeth Tran; Haiyan Sun; Ye Fang
Journal: Assay Drug Dev Technol Date: 2011-11-08 Impact factor: 1.738

2. Resonant waveguide grating imager for live cell sensing.

Authors: Ann M Ferrie; Qi Wu; Ye Fang
Journal: Appl Phys Lett Date: 2010-12-01 Impact factor: 3.791

Review 3. New concepts in pharmacological efficacy at 7TM receptors: IUPHAR review 2.

Authors: Terry Kenakin
Journal: Br J Pharmacol Date: 2013-02 Impact factor: 8.739

4. Measuring Stepwise Binding of Thermally Fluctuating Particles to Cell Membranes without Fluorescence.

Authors: Alexander Rohrbach; Tim Meyer; Ernst H K Stelzer; Holger Kress
Journal: Biophys J Date: 2020-03-14 Impact factor: 4.033

Review 5. Allosteric modulation and functional selectivity of G protein-coupled receptors.

Authors: Zhan-Guo Gao; Kenneth A Jacobson
Journal: Drug Discov Today Technol Date: 2013

6. PROBING CANCER SIGNALING WITH RESONANT WAVEGUIDE GRATING BIOSENSORS.

Authors: Ye Fang
Journal: Expert Opin Drug Discov Date: 2010-12 Impact factor: 6.098

7. Label-free cell phenotypic assessment of the biased agonism and efficacy of agonists at the endogenous muscarinic M3 receptors.

Authors: Huayun Deng; Haiyan Sun; Ye Fang
Journal: J Pharmacol Toxicol Methods Date: 2013-08-09 Impact factor: 1.950