Literature DB >> 21221404

Risks Associated with Treating Hypothyroidism: Potential hazards of L-thyroxine therapy.

H C Gerstein.   

Abstract

Most patients with hypothyroidism can be treated simply and safely with physiologic replacement dosages of L-thyroxine. Recently, concerns have been raised about potential hazards of L-thyroxine therapy, including a possible increased risk of osteoporosis and ischemic heart disease. The author reviews these concerns and describes a modern approach to initiation and maintenance of thyroid hormone replacement therapy.

Entities:  

Year:  1992        PMID： 21221404      PMCID： PMC2146155     

Source DB:  PubMed          Journal:  Can Fam Physician        ISSN： 0008-350X            Impact factor:   3.275


  30 in total

1.  The spectrum of thyroid disease in a community: the Whickham survey.

Authors:  W M Tunbridge; D C Evered; R Hall; D Appleton; M Brewis; F Clark; J G Evans; E Young; T Bird; P A Smith
Journal:  Clin Endocrinol (Oxf)       Date:  1977-12       Impact factor: 3.478

2.  L-Thyroxine therapy in subclinical hypothyroidism. A double-blind, placebo-controlled trial.

Authors:  D S Cooper; R Halpern; L C Wood; A A Levin; E C Ridgway
Journal:  Ann Intern Med       Date:  1984-07       Impact factor: 25.391

3.  Thyroid supplements: effect on bone mass.

Authors:  B Ettinger; J Wingerd
Journal:  West J Med       Date:  1982-06

4.  Noninvasive evaluation of cardiac function in hypothyroidism. Response to gradual thyroxine replacement.

Authors:  W F Crowley; E C Ridgway; E W Bough; G S Francis; G H Daniels; I A Kourides; G S Myers; F Maloof
Journal:  N Engl J Med       Date:  1977-01-06       Impact factor: 91.245

5.  Diagnosis and management of the hypothyroid patient with chest pain.

Authors:  P D Myerowitz; R W Kamienski; D K Swanson; P S Chopra; H A Berkoff; G M Kroncke; G G Rowe; C R Vander Ark; S P Dhanani
Journal:  J Thorac Cardiovasc Surg       Date:  1983-07       Impact factor: 5.209

6.  Spinal bone mineral content in myxoedema and thyrotoxicosis. Effects of thyroid hormone(s) and antithyroid treatment.

Authors:  B Krølner; J V Jørgensen; S P Nielsen
Journal:  Clin Endocrinol (Oxf)       Date:  1983-05       Impact factor: 3.478

7.  Direct stimulation of bone resorption by thyroid hormones.

Authors:  G R Mundy; J L Shapiro; J G Bandelin; E M Canalis; L G Raisz
Journal:  J Clin Invest       Date:  1976-09       Impact factor: 14.808

8.  Osteoporosis in hyperthyroidism estimated by photon absorptiometry.

Authors:  J Linde; T Friis
Journal:  Acta Endocrinol (Copenh)       Date:  1979-07

9.  Morphometric and dynamic studies of bone changes in hypothyroidism.

Authors:  L Mosekilde; F Melsen
Journal:  Acta Pathol Microbiol Scand A       Date:  1978-01

10.  Natural history of autoimmune thyroiditis.

Authors:  W M Tunbridge; M Brewis; J M French; D Appleton; T Bird; F Clark; D C Evered; J G Evans; R Hall; P Smith; J Stephenson; E Young
Journal:  Br Med J (Clin Res Ed)       Date:  1981-01-24
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