Literature DB >> 21220896

Standard guidelines of care: Keloids and hypertrophic scars.

Somesh Gupta1, V K Sharma.   

Abstract

Keloids and hypertrophic scars (HTS) are the result of overgrowth of fibrous tissue, following healing of a cutaneous injury, and cause morbidity. There are several treatment modalities which are useful for the management of keloids, though no single modality is completely effective. The most commonly used modalities are pressure, silicone gel sheet, intralesional steroids, 5-fluorouracil (5 FU), cryotherapy, surgical excision, and lasers. They may be used either singly or, as is done more commonly, in combinations. Any qualified dermatologist who has attained postgraduate qualification in dermatology can treat keloids and HTS. Some procedures, such as cryosurgery and surgical excision, may require additional training in dermatologic surgery. Most modalities for keloids, including intralesional injections and mechanical therapies such as pressure and silicone gel based products, can be given/prescribed on OPD basis. Surgical excision requires a minor operation theater with the facility to handle emergencies. It is important to counsel the patient about the nature of the problem. One should realize that keloid will only improve and not disappear completely. Patients should be informed about the high recurrence rates. Different modalities carry risk of adverse effects and complications and the treating physician needs to be aware of these and patients should be informed about them.

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Year:  2011        PMID: 21220896     DOI: 10.4103/0378-6323.74968

Source DB:  PubMed          Journal:  Indian J Dermatol Venereol Leprol        ISSN: 0378-6323            Impact factor:   2.545


  15 in total

1.  Analysis of Keloid Response to 5-Fluorouracil Treatment and Long-Term Prevention of Keloid Recurrence.

Authors:  Ryan LaRanger; Anis Karimpour-Fard; Christopher Costa; David Mathes; Woodring E Wright; Tae Chong
Journal:  Plast Reconstr Surg       Date:  2019-02       Impact factor: 4.730

2.  HIF-1α promotes the keloid development through the activation of TGF-β/Smad and TLR4/MyD88/NF-κB pathways.

Authors:  Rui Lei; Jian Li; Feng Liu; Weihan Li; Shizhen Zhang; Yang Wang; Xi Chu; Jinghong Xu
Journal:  Cell Cycle       Date:  2019-10-23       Impact factor: 4.534

Review 3.  Skin sonography in children: a review.

Authors:  Cristian Garcia; Ximena Wortsman; Diego Bazaes-Nuñez; Mario Pelizzari; Sergio Gonzalez; Maria-Laura Cossio; Florencia De Barbieri
Journal:  Pediatr Radiol       Date:  2022-07-12

Review 4.  Laser therapy for treating hypertrophic and keloid scars.

Authors:  Rafael Leszczynski; Carolina Ap da Silva; Ana Carolina Pereira Nunes Pinto; Uliana Kuczynski; Edina Mk da Silva
Journal:  Cochrane Database Syst Rev       Date:  2022-09-26

Review 5.  Efficacy and safety of triamcinolone acetonide alone and in combination with 5-fluorouracil for treating hypertrophic scars and keloids: a systematic review and meta-analysis.

Authors:  YiMing Ren; XianHu Zhou; ZhiJian Wei; Wei Lin; BaoYou Fan; ShiQing Feng
Journal:  Int Wound J       Date:  2016-07-18       Impact factor: 3.315

6.  Intralesional steroid injections: look before you leap!

Authors:  Bhushan Premanshu; Manjul Prateek; Lata Swarn
Journal:  Indian J Dermatol       Date:  2014-07       Impact factor: 1.494

7.  LETTER TO THE EDITOR Abnormal Responses of Keloid Tissue to Wounding Identified Using In Vitro Model System.

Authors:  Dorothy M Supp; Kathryn Glaser; Jennifer M Hahn; Kevin L McFarland; Steven T Boyce
Journal:  Eplasty       Date:  2012-04-12

Review 8.  Intralesional Cryotherapy for the Treatment of Keloid Scars: Evaluating Effectiveness.

Authors:  Michiel C E van Leeuwen; Anne Eva J Bulstra; Johannes C F Ket; Marco J P F Ritt; Paul A M van Leeuwen; Frank B Niessen
Journal:  Plast Reconstr Surg Glob Open       Date:  2015-07-08

9.  Efficacy of triple therapy in auricular keloids.

Authors:  Reuben F De Sousa; Bijitesh Chakravarty; Alok Sharma; M Alam Parwaz; Anil Malik
Journal:  J Cutan Aesthet Surg       Date:  2014-04

10.  Cryotherapy in treatment of keloids: evaluation of factors affecting treatment outcome.

Authors:  Meenu Barara; Vibhu Mendiratta; Ram Chander
Journal:  J Cutan Aesthet Surg       Date:  2012-07
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