Literature DB >> 21220528

Restoration of chloride efflux by azithromycin in airway epithelial cells of cystic fibrosis patients.

Vinciane Saint-Criq1, Carine Rebeyrol, Manon Ruffin, Telma Roque, Loïc Guillot, Jacky Jacquot, Annick Clement, Olivier Tabary.   

Abstract

Azithromycin (AZM) has shown promising anti-inflammatory properties in chronic obstructive pulmonary diseases, and clinical studies have presented an improvement in the respiratory condition of cystic fibrosis (CF) patients. The aim of this study was to investigate, in human airway cells, the mechanism by which AZM has beneficial effects in CF. We demonstrated that AZM did not have any anti-inflammatory effect on CF airway cells but restored Cl(-) efflux.

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Year:  2011        PMID： 21220528      PMCID： PMC3067177          DOI： 10.1128/AAC.01403-10

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  8 in total

Review 1.  The role of azithromycin in patients with cystic fibrosis.

Authors:  Abdullah A Yousef; Adam Jaffe
Journal:  Paediatr Respir Rev       Date:  2010-01-21       Impact factor: 2.726

2.  Calcium-dependent regulation of NF-(kappa)B activation in cystic fibrosis airway epithelial cells.

Authors:  Olivier Tabary; Emilie Boncoeur; Rainer de Martin; Rainer Pepperkok; Annick Clément; Carsten Schultz; Jacky Jacquot
Journal:  Cell Signal       Date:  2005-08-09       Impact factor: 4.315

3.  Long term effects of azithromycin in patients with cystic fibrosis: A double blind, placebo controlled trial.

Authors:  A Clement; A Tamalet; E Leroux; S Ravilly; B Fauroux; J-P Jais
Journal:  Thorax       Date:  2006-06-29       Impact factor: 9.139

4.  Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA.

Authors:  J R Riordan; J M Rommens; B Kerem; N Alon; R Rozmahel; Z Grzelczak; J Zielenski; S Lok; N Plavsic; J L Chou
Journal:  Science       Date:  1989-09-08       Impact factor: 47.728

5.  Airway epithelial tight junctions and binding and cytotoxicity of Pseudomonas aeruginosa.

Authors:  A Lee; D Chow; B Haus; W Tseng; D Evans; S Fleiszig; G Chandy; T Machen
Journal:  Am J Physiol       Date:  1999-07

6.  CFTR inhibition mimics the cystic fibrosis inflammatory profile.

Authors:  Aura Perez; Amanda C Issler; Calvin U Cotton; Thomas J Kelley; Alan S Verkman; Pamela B Davis
Journal:  Am J Physiol Lung Cell Mol Physiol       Date:  2006-08-18       Impact factor: 5.464

7.  Azithromycin increases chloride efflux from cystic fibrosis airway epithelial cells.

Authors:  Igor Oliynyk; Georgia Varelogianni; Martin Schalling; Monika Stenkvist Asplund; Godfried M Roomans; Marie Johannesson
Journal:  Exp Lung Res       Date:  2009-04       Impact factor: 2.459

8.  CFTR is a negative regulator of NFkappaB mediated innate immune response.

Authors:  Neeraj Vij; Steven Mazur; Pamela L Zeitlin
Journal:  PLoS One       Date:  2009-02-27       Impact factor: 3.240
  8 in total
  1 in total

1.  Azithromycin attenuates cigarette smoke extract-induced oxidative stress injury in human alveolar epithelial cells.

Authors:  Miaomiao Chen; Tuo Yang; Xiangiyu Meng; Tieying Sun
Journal:  Mol Med Rep       Date:  2015-01-20       Impact factor: 2.952
  1 in total

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