Karunakaran Indulekha1, Ranjith Mohan Anjana, Jayagopi Surendar, Viswanathan Mohan. 1. Madras Diabetes Research Foundation and Dr. Mohan's Diabetes Specialities Centre, WHO Collaborating Centre for Non-Communicable Diseases Prevention and Control, International Diabetes Federation (IDF) Centre for Education, Gopalapuram, Chennai 600086, India.
Abstract
OBJECTIVES: The aim of the study was to assess the association between visceral and subcutaneous fat with glucose intolerance, adipocytokines, inflammatory markers and carotid IMT in Asian Indians. DESIGN AND METHODS: Subjects with NGT (n=85), IGT (n=49) and T2DM (n=93) were randomly selected from CURES. Total abdominal, visceral and subcutaneous fat were measured using Helical CT scan. Adiponectin, hs-CRP, TNF-alpha, oxidized LDL, visfatin and leptin and IMT and insulin resistance were assessed. RESULTS: Total abdominal fat (p=0.041) and the visceral fat (p=0.039) but not subcutaneous fat progressively increased from NGT, IGT and T2DM subjects. With increasing quartiles of visceral fat, there was a significant increase in insulin resistance (p=0.040); significant decrease in adiponectin (p=0.043) and increase in TNF-alpha (p=0.028), hs-CRP (p=0.043), OX-LDL (p=0.034) and visfatin (p=0.040), and carotid IMT (p=0.047) was observed. CONCLUSION: Visceral fat levels increased with increasing glucose intolerance and are associated with decreased levels of adiponectin and increased levels of hs-CRP, TNF-alpha, oxidized LDL, visfatin, HOMA-IR and IMT.
OBJECTIVES: The aim of the study was to assess the association between visceral and subcutaneous fat with glucose intolerance, adipocytokines, inflammatory markers and carotid IMT in Asian Indians. DESIGN AND METHODS: Subjects with NGT (n=85), IGT (n=49) and T2DM (n=93) were randomly selected from CURES. Total abdominal, visceral and subcutaneous fat were measured using Helical CT scan. Adiponectin, hs-CRP, TNF-alpha, oxidized LDL, visfatin and leptin and IMT and insulin resistance were assessed. RESULTS: Total abdominal fat (p=0.041) and the visceral fat (p=0.039) but not subcutaneous fat progressively increased from NGT, IGT and T2DM subjects. With increasing quartiles of visceral fat, there was a significant increase in insulin resistance (p=0.040); significant decrease in adiponectin (p=0.043) and increase in TNF-alpha (p=0.028), hs-CRP (p=0.043), OX-LDL (p=0.034) and visfatin (p=0.040), and carotid IMT (p=0.047) was observed. CONCLUSION: Visceral fat levels increased with increasing glucose intolerance and are associated with decreased levels of adiponectin and increased levels of hs-CRP, TNF-alpha, oxidized LDL, visfatin, HOMA-IR and IMT.
Authors: Elena Flowers; Feng Lin; Namratha R Kandula; Matthew Allison; Jeffrey J Carr; Jingzhong Ding; Ravi Shah; Kiang Liu; David Herrington; Alka M Kanaya Journal: Diabetes Care Date: 2019-02-22 Impact factor: 19.112
Authors: Leonardo Roever; Elmiro S Resende; Fernando C Veloso; Angélica L D Diniz; Nilson Penha-Silva; Antonio Casella-Filho; Paulo M M Dourado; Antonio C P Chagas Journal: Medicine (Baltimore) Date: 2015-09 Impact factor: 1.889
Authors: Unhee Lim; Stephen D Turner; Adrian A Franke; Robert V Cooney; Lynne R Wilkens; Thomas Ernst; Cheryl L Albright; Rachel Novotny; Linda Chang; Laurence N Kolonel; Suzanne P Murphy; Loïc Le Marchand Journal: PLoS One Date: 2012-08-17 Impact factor: 3.240