Literature DB >> 2121939

Cellular uptake and photosensitizing properties of anticancer porphyrins in cell membranes and low and high density lipoproteins.

J C Maziere1, R Santus, P Morliere, J P Reyftmann, C Candide, L Mora, S Salmon, C Maziere, S Gatt, L Dubertret.   

Abstract

The mechanisms of the phototoxic effect of anticancer porphyrins used in the photodynamic therapy (PDT) of tumours are not yet completely understood. Irradiation of porphyrins gives rise to singlet oxygen which reacts with key residues of proteins, polyunsaturated fatty acids and cholesterol in membranes, leading to inactivation of various enzymes and transporters. Lipoproteins, mainly low density lipoproteins (LDL), are efficient carriers of anticancer porphyrins in blood and can deliver these photosensitizers to tissues through the apolipoprotein (apo) B/E specific LDL receptor pathway. In this review, we discuss some aspects of anticancer porphyrin transport, cellular uptake and photosensitizing properties in cell membranes and lipoproteins.

Entities:  

Mesh：

Substances：

Year:  1990        PMID： 2121939     DOI： 10.1016/1011-1344(90)85074-7

Source DB:  PubMed          Journal:  J Photochem Photobiol B        ISSN： 1011-1344            Impact factor:   6.252


  10 in total

Review 1.  Interaction of porphyrins with heme proteins--a brief review.

Authors:  Abhay Sankar Chakraborti
Journal:  Mol Cell Biochem       Date:  2003-11       Impact factor: 3.396

2.  Mechanisms in photodynamic therapy: Part three-Photosensitizer pharmacokinetics, biodistribution, tumor localization and modes of tumor destruction.

Authors:  Ana P Castano; Tatiana N Demidova; Michael R Hamblin
Journal:  Photodiagnosis Photodyn Ther       Date:  2005-08-10       Impact factor: 3.631

3.  Chiral porphyrazine near-IR optical imaging agent exhibiting preferential tumor accumulation.

Authors:  Evan R Trivedi; Allison S Harney; Mary B Olive; Izabela Podgorski; Kamiar Moin; Bonnie F Sloane; Anthony G M Barrett; Thomas J Meade; Brian M Hoffman
Journal:  Proc Natl Acad Sci U S A       Date:  2009-12-23       Impact factor: 11.205

4.  Efficient synthesis and photodynamic activity of porphyrin-saccharide conjugates: targeting and incapacitating cancer cells.

Authors:  Xin Chen; Li Hui; David A Foster; Charles Michael Drain
Journal:  Biochemistry       Date:  2004-08-31       Impact factor: 3.162

5.  Radiosynthesis and bioevaluation of [68Ga]-labeled 5,10,15,20-tetra(4-methylpyridyl)-porphyrin for possible application as a PET radiotracer for tumor imaging.

Authors:  Mohini Bhadwal; Tapas Das; Haladhar Dev Sarma; Sharmila Banerjee
Journal:  Mol Imaging Biol       Date:  2015-02       Impact factor: 3.488

6.  Association of antisense oligonucleotides with lipoproteins prolongs the plasma half-life and modifies the tissue distribution.

Authors:  P C de Smidt; T Le Doan; S de Falco; T J van Berkel
Journal:  Nucleic Acids Res       Date:  1991-09-11       Impact factor: 16.971

7.  Photodynamic targeting of human retinoblastoma cells using covalent low-density lipoprotein conjugates.

Authors:  U Schmidt-Erfurth; H Diddens; R Birngruber; T Hasan
Journal:  Br J Cancer       Date:  1997       Impact factor: 7.640

8.  Carotenoporphyrins as selective photodiagnostic agents for tumours.

Authors:  E Reddi; A Segalla; G Jori; P K Kerrigan; P A Liddell; A L Moore; T A Moore; D Gust
Journal:  Br J Cancer       Date:  1994-01       Impact factor: 7.640

9.  In vivo fluorescence and photodynamic activity of zinc phthalocyanine administered in liposomes.

Authors:  H L van Leengoed; V Cuomo; A A Versteeg; N van der Veen; G Jori; W M Star
Journal:  Br J Cancer       Date:  1994-05       Impact factor: 7.640

10.  Evidence for low-density lipoprotein receptor-mediated uptake of benzoporphyrin derivative.

Authors:  B A Allison; P H Pritchard; J G Levy
Journal:  Br J Cancer       Date:  1994-05       Impact factor: 7.640
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.