BACKGROUND: Transient lower oesophageal sphincter relaxations (TLOSR) are considered the physiological mechanism that enables venting of gas from the stomach and appear as sphincter relaxations that are not induced by swallowing. It has become increasingly clear that most reflux episodes occur during TLOSRs and therefore play a key role in gastro-oesophageal reflux disease (GERD). AIM: To describe the current knowledge about TLOSRs and its clinical implications. METHODS: Search of the literature published in English using the PubMed database and relevant abstracts presented at international conventions. RESULTS: Several factors influence the rate of TLOSRs including anti-reflux surgery, meal, body position, nutrition, lifestyle and a wide array of neurotransmitters. Ongoing insights in the neurotransmitters responsible for the modulation of TLOSRs, as well as the neural pathways involved in TLOSR induction, have lead to novel therapeutic targets. These therapeutic targets can serve as an add-on therapy in patients with an unsatisfactory response to proton pump inhibitor by inhibiting TLOSRs and its associated reflux events. However, the TLOSR-inhibiting drugs that are currently available still have significant side effects. CONCLUSION: It is likely that in the future, selected GERD patients may benefit from transient lower oesophageal sphincter relaxation inhibition when compounds are found without significant side effects.
BACKGROUND: Transient lower oesophageal sphincter relaxations (TLOSR) are considered the physiological mechanism that enables venting of gas from the stomach and appear as sphincter relaxations that are not induced by swallowing. It has become increasingly clear that most reflux episodes occur during TLOSRs and therefore play a key role in gastro-oesophageal reflux disease (GERD). AIM: To describe the current knowledge about TLOSRs and its clinical implications. METHODS: Search of the literature published in English using the PubMed database and relevant abstracts presented at international conventions. RESULTS: Several factors influence the rate of TLOSRs including anti-reflux surgery, meal, body position, nutrition, lifestyle and a wide array of neurotransmitters. Ongoing insights in the neurotransmitters responsible for the modulation of TLOSRs, as well as the neural pathways involved in TLOSR induction, have lead to novel therapeutic targets. These therapeutic targets can serve as an add-on therapy in patients with an unsatisfactory response to proton pump inhibitor by inhibiting TLOSRs and its associated reflux events. However, the TLOSR-inhibiting drugs that are currently available still have significant side effects. CONCLUSION: It is likely that in the future, selected GERDpatients may benefit from transient lower oesophageal sphincter relaxation inhibition when compounds are found without significant side effects.
Authors: J Halicka; P Banovcin; M Halickova; M Demeter; R Hyrdel; M Tatar; M Kollarik Journal: Neurogastroenterol Motil Date: 2014-08-22 Impact factor: 3.598
Authors: Terry L Powley; Elizabeth A Baronowsky; Jared M Gilbert; Cherie N Hudson; Felecia N Martin; Jacqueline K Mason; Jennifer L McAdams; Robert J Phillips Journal: Auton Neurosci Date: 2013-04-11 Impact factor: 3.145
Authors: Nicolaas F Rinsma; Fabiënne G Smeets; Daisy W Bruls; Boudewijn F Kessing; Nicole D Bouvy; Ad A M Masclee; José M Conchillo Journal: Surg Endosc Date: 2013-10-23 Impact factor: 4.584
Authors: Boudewijn F Kessing; Joris A J L Broeders; Nikki Vinke; Marlies P Schijven; Eric J Hazebroek; Ivo A M J Broeders; Albert J Bredenoord; André J P M Smout Journal: Surg Endosc Date: 2013-05-01 Impact factor: 4.584