OBJECTIVE: This study aimed at determining brain structural imaging correlates of neurological soft signs (NSS) in patients suffering from a first-episode psychosis. METHOD: Fifty-two patients with a DSMIV diagnosis of first-episode psychosis (schizophrenia or schizophrenia spectrum disorder) were consecutively included. Subjects were assessed using a standardized neurological examination for motor coordination, motor integration and sensory integration. Anatomical magnetic resonance images (MRI) were analysed in the whole brain using optimized voxel-based morphometry. RESULTS: Neurological soft signs (NSS) total score (P-corrected = 0.013) and motor integration subscore (P-corrected = 0.035) were found to negatively correlate with grey matter structure of the dorsolateral prefrontal cortices. Motor coordination subscore was positively correlated with grey matter structure of the thalami (P-corrected = 0.002) and negatively with white matter structure of the cerebellum (P-corrected = 0.034). The addition of age and gender as covariate yielded similar results. We did not find any correlation between neither sensory integration subscore and grey matter structure nor NSS total score, motor integration subscore and voxel-based morphometry (VBM) white matter structure. CONCLUSION: Structural alteration in the cerebello-thalamo-prefrontal network is associated with neurological soft signs in schizophrenia, a candidate network for 'cognitive dysmetria'.
OBJECTIVE: This study aimed at determining brain structural imaging correlates of neurological soft signs (NSS) in patients suffering from a first-episode psychosis. METHOD: Fifty-two patients with a DSMIV diagnosis of first-episode psychosis (schizophrenia or schizophrenia spectrum disorder) were consecutively included. Subjects were assessed using a standardized neurological examination for motor coordination, motor integration and sensory integration. Anatomical magnetic resonance images (MRI) were analysed in the whole brain using optimized voxel-based morphometry. RESULTS: Neurological soft signs (NSS) total score (P-corrected = 0.013) and motor integration subscore (P-corrected = 0.035) were found to negatively correlate with grey matter structure of the dorsolateral prefrontal cortices. Motor coordination subscore was positively correlated with grey matter structure of the thalami (P-corrected = 0.002) and negatively with white matter structure of the cerebellum (P-corrected = 0.034). The addition of age and gender as covariate yielded similar results. We did not find any correlation between neither sensory integration subscore and grey matter structure nor NSS total score, motor integration subscore and voxel-based morphometry (VBM) white matter structure. CONCLUSION: Structural alteration in the cerebello-thalamo-prefrontal network is associated with neurological soft signs in schizophrenia, a candidate network for 'cognitive dysmetria'.
Authors: Vijay A Mittal; Derek J Dean; Jessica A Bernard; Joseph M Orr; Andrea Pelletier-Baldelli; Emily E Carol; Tina Gupta; Jessica Turner; Daniel R Leopold; Briana L Robustelli; Zachary B Millman Journal: Schizophr Bull Date: 2013-12-27 Impact factor: 9.306
Authors: Qing Zhao; Zhi Li; Jia Huang; Chao Yan; Paola Dazzan; Christos Pantelis; Eric F C Cheung; Simon S Y Lui; Raymond C K Chan Journal: Schizophr Bull Date: 2013-05-13 Impact factor: 9.306
Authors: Melissa K Licari; Jac Billington; Siobhan L Reid; John P Wann; Catherine M Elliott; Anne M Winsor; Erin Robins; Ashleigh L Thornton; Randall Jones; Michael Bynevelt Journal: Exp Brain Res Date: 2015-03-11 Impact factor: 1.972
Authors: Raymond C K Chan; Fu-Lei Geng; Simon S Y Lui; Ya Wang; Karen K Y Ho; Karen S Y Hung; Raquel E Gur; Ruben C Gur; Eric F C Cheung Journal: Sci Rep Date: 2015-06-08 Impact factor: 4.379
Authors: Raymond C K Chan; Jia Huang; Qing Zhao; Ya Wang; Yun-yao Lai; Nan Hong; David H K Shum; Eric F C Cheung; Xin Yu; Paola Dazzan Journal: Neuroimage Clin Date: 2015-09-18 Impact factor: 4.881