OBJECTIVE: To evaluate the effectiveness of the Mississippi Protocol (MP) to treat HELLP (hemolysis, elevated liver enzymes, and low platelets) syndrome. METHODS: Uniform early initiation of MP (corticosteroids, magnesium sulfate, systolic blood pressure control) was studied prospectively in patients admitted with severe preeclampsia/class 1 or class 2 HELLP syndrome. RESULTS: One hundred and ninety patients between 2000 and 2007 received MP without suffering maternal death, stroke, or liver rupture. Only 39 of 163 patients (24%) not class 1 when MP began progressed to class 1 disease; only 18.2% of class 1 and 2.4% of class 2 subsequently developed major maternal morbidity. CONCLUSION: Early initiation of MP inhibits HELLP syndrome disease progression and severity.
OBJECTIVE: To evaluate the effectiveness of the Mississippi Protocol (MP) to treat HELLP (hemolysis, elevated liver enzymes, and low platelets) syndrome. METHODS: Uniform early initiation of MP (corticosteroids, magnesium sulfate, systolic blood pressure control) was studied prospectively in patients admitted with severe preeclampsia/class 1 or class 2 HELLP syndrome. RESULTS: One hundred and ninety patients between 2000 and 2007 received MP without suffering maternal death, stroke, or liver rupture. Only 39 of 163 patients (24%) not class 1 when MP began progressed to class 1 disease; only 18.2% of class 1 and 2.4% of class 2 subsequently developed major maternal morbidity. CONCLUSION: Early initiation of MP inhibits HELLP syndrome disease progression and severity.
Authors: Sarah Novotny; Nicole Lee-Plenty; Kedra Wallace; Wondwosen Kassahun-Yimer; Aswathi Jayaram; James A Bofill; James N Martin Journal: Pregnancy Hypertens Date: 2020-01-09 Impact factor: 2.899
Authors: Seung Mi Lee; Ju-Yeon Moon; Byeong-Yun Lim; Sun Min Kim; Chan-Wook Park; Byoung Jae Kim; Jong Kwan Jun; Errol R Norwitz; Man Ho Choi; Joong Shin Park Journal: Sci Rep Date: 2019-02-07 Impact factor: 4.379
Authors: Kestutis Rimaitis; Lina Grauslyte; Asta Zavackiene; Vilda Baliuliene; Ruta Nadisauskiene; Andrius Macas Journal: Int J Environ Res Public Health Date: 2019-01-03 Impact factor: 3.390