Literature DB >> 21218498

Nano-CuO inhibited voltage-gated sodium current of hippocampal CA1 neurons via reactive oxygen species but independent from G-proteins pathway.

Zhaowei Liu1, Shichang Liu, Guogang Ren, Tao Zhang, Zhuo Yang.   

Abstract

The aim of this study was to investigate the effects of nano-CuO on voltage-gated sodium current (I(Na) ) in hippocampal CA1 neurons. The results suggested that nano-CuO inhibited amplitudes of I(Na) currents and prolonged peak rise time of action potential (AP). The responses to nano-CuO were inhibited by reactive oxygen species (ROS) scavenger. However, the G-proteins inhibitor did not block the effects of nano-CuO. The effects of nano-CuO were mediated through activation of ROS-I(Na) -AP signaling cascades and independent from G-proteins pathway.
Copyright © 2011 John Wiley & Sons, Ltd.

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Year:  2011        PMID： 21218498     DOI： 10.1002/jat.1611

Source DB:  PubMed          Journal:  J Appl Toxicol        ISSN： 0260-437X            Impact factor:   3.446


  5 in total

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Authors:  Mohammed Y I Al-Hamadani; Abdullah M Alzahrani; Mokhtar I Yousef; Maher A Kamel; Wael M El-Sayed
Journal:  Int J Nanomedicine       Date:  2020-07-14

2.  Characterisation of the Chemical Composition and Structural Features of Novel Antimicrobial Nanoparticles.

Authors:  Yuen-Ki Cheong; Jesus Calvo-Castro; Lena Ciric; Mohan Edirisinghe; Elaine Cloutman-Green; Upulitha Eranka Illangakoon; Qiang Kang; Suntharavathanan Mahalingam; Rupy Kaur Matharu; Rory M Wilson; Guogang Ren
Journal:  Nanomaterials (Basel)       Date:  2017-06-23       Impact factor: 5.076

3.  SiO2 nanoparticles modulate the electrical activity of neuroendocrine cells without exerting genomic effects.

Authors:  C Distasi; F A Ruffinatti; M Dionisi; S Antoniotti; A Gilardino; G Croci; B Riva; E Bassino; G Alberto; E Castroflorio; D Incarnato; E Morandi; G Martra; S Oliviero; L Munaron; D Lovisolo
Journal:  Sci Rep       Date:  2018-02-09       Impact factor: 4.379

Review 4.  Nano-Neurotheranostics: Impact of Nanoparticles on Neural Dysfunctions and Strategies to Reduce Toxicity for Improved Efficacy.

Authors:  Chiluka Vinod; Srikanta Jena
Journal:  Front Pharmacol       Date:  2021-03-26       Impact factor: 5.810

Review 5.  Neurotoxicity of nanoscale materials.

Authors:  Alokita Karmakar; Qinli Zhang; Yongbin Zhang
Journal:  J Food Drug Anal       Date:  2014-02-04       Impact factor: 6.157
  5 in total

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