Literature DB >> 2121828

The use of diphenylene iodonium, an inhibitor of NADPH oxidase, to investigate the antimicrobial action of human monocyte derived macrophages.

A K Robertson1, A R Cross, O T Jones, P W Andrew.   

Abstract

Diphenylene iodonium is an inhibitor of the respiratory burst-generating NADPH oxidase of phagocytes. The effect of this compound on human monocyte-derived macrophages and its usefulness in exploring the antimicrobial mechanisms of phagocytes was examined. 1 microM diphenylene iodonium inhibited hydrogen peroxide production by human macrophages and the activity of these cells against Toxoplasma gondii. At this concentration macrophage degranulation was unaffected.

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Year:  1990        PMID： 2121828     DOI： 10.1016/0022-1759(90)90357-2

Source DB:  PubMed          Journal:  J Immunol Methods        ISSN： 0022-1759            Impact factor:   2.303


  15 in total

1.  Simultaneous activation of NADPH oxidase-related proton and electron currents in human neutrophils.

Authors:  T E DeCoursey; V V Cherny; W Zhou; L L Thomas
Journal:  Proc Natl Acad Sci U S A       Date:  2000-06-06       Impact factor: 11.205

2.  Analysis of electrophysiological properties and responses of neutrophils.

Authors:  Deri Morgan; Thomas E Decoursey
Journal:  Methods Mol Biol       Date:  2014

3.  Biophysical properties of the voltage gated proton channel H(V)1.

Authors:  Boris Musset; Thomas Decoursey
Journal:  Wiley Interdiscip Rev Membr Transp Signal       Date:  2012-05-11

4.  Interactions between NADPH oxidase-related proton and electron currents in human eosinophils.

Authors:  T E DeCoursey; V V Cherny; A G DeCoursey; W Xu; L L Thomas
Journal:  J Physiol       Date:  2001-09-15       Impact factor: 5.182

5.  Activation of NADPH oxidase-related proton and electron currents in human eosinophils by arachidonic acid.

Authors:  V V Cherny; L M Henderson; W Xu; L L Thomas; T E DeCoursey
Journal:  J Physiol       Date:  2001-09-15       Impact factor: 5.182

6.  NOX2 deficiency attenuates markers of adiposopathy and brain injury induced by high-fat diet.

Authors:  Jennifer K Pepping; Linnea R Freeman; Sunita Gupta; Jeffrey N Keller; Annadora J Bruce-Keller
Journal:  Am J Physiol Endocrinol Metab       Date:  2012-12-11       Impact factor: 4.310

Review 7.  The intimate and controversial relationship between voltage-gated proton channels and the phagocyte NADPH oxidase.

Authors:  Thomas E DeCoursey
Journal:  Immunol Rev       Date:  2016-09       Impact factor: 12.988

8.  Localization of a constitutively active, phagocyte-like NADPH oxidase in rabbit aortic adventitia: enhancement by angiotensin II.

Authors:  P J Pagano; J K Clark; M E Cifuentes-Pagano; S M Clark; G M Callis; M T Quinn
Journal:  Proc Natl Acad Sci U S A       Date:  1997-12-23       Impact factor: 11.205

9.  Temperature dependence of NADPH oxidase in human eosinophils.

Authors:  Deri Morgan; Vladimir V Cherny; Ricardo Murphy; Wei Xu; Larry L Thomas; Thomas E DeCoursey
Journal:  J Physiol       Date:  2003-05-16       Impact factor: 5.182

10.  Interferon-gamma activates the oxidative killing of Candida albicans by human granulocytes.

Authors:  A Stevenhagen; R van Furth
Journal:  Clin Exp Immunol       Date:  1993-01       Impact factor: 4.330
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