Literature DB >> 212173

Human colon tumors: enzymic and histological characteristics.

A Herzfeld, M A Legg, O Greengard.   

Abstract

In samples of colonic adenocarcinomas, the mean activities of thymidine kinase, glucose-6-phosphate dehydrogenase, phosphoserine phosphatase and pyrroline-5-carboxylate reductase were several fold higher than those of nonneoplastic colon. The presence of considerable, cold labile pyrroline-5-carboxylate reductase activity provided an additional criterion for distinguishing tumors from the control tissue. Deviations from the pattern of enzymes in normal colon were much more pronounced in the five moderately well-differentiated than in the single well-differentiated adenocarcinoma.

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Year:  1978        PMID: 212173     DOI: 10.1002/1097-0142(197809)42:3<1280::aid-cncr2820420337>3.0.co;2-p

Source DB:  PubMed          Journal:  Cancer        ISSN: 0008-543X            Impact factor:   6.860


  5 in total

1.  Promotion of colorectal neoplasia in experimental murine ulcerative colitis.

Authors:  I Okayasu; T Ohkusa; K Kajiura; J Kanno; S Sakamoto
Journal:  Gut       Date:  1996-07       Impact factor: 23.059

2.  Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation.

Authors:  Jiangbin Ye; Anthony Mancuso; Xuemei Tong; Patrick S Ward; Jing Fan; Joshua D Rabinowitz; Craig B Thompson
Journal:  Proc Natl Acad Sci U S A       Date:  2012-04-16       Impact factor: 11.205

Review 3.  Proline metabolism and microenvironmental stress.

Authors:  James M Phang; Wei Liu; Olga Zabirnyk
Journal:  Annu Rev Nutr       Date:  2010-08-21       Impact factor: 11.848

4.  Muscle wasting and interleukin-6-induced atrogin-I expression in the cachectic Apc ( Min/+ ) mouse.

Authors:  Kristen A Baltgalvis; Franklin G Berger; Maria Marjorette O Peña; J Mark Davis; James P White; James A Carson
Journal:  Pflugers Arch       Date:  2008-08-19       Impact factor: 3.657

5.  Phosphoserine Phosphatase Promotes Lung Cancer Progression through the Dephosphorylation of IRS-1 and a Noncanonical L-Serine-Independent Pathway.

Authors:  Seong-Min Park; Eun-Hye Seo; Dong-Hyuck Bae; Sung Soo Kim; Jina Kim; Weiwei Lin; Kyung-Hee Kim; Jong Bae Park; Yong Sung Kim; Jinlong Yin; Seon-Young Kim
Journal:  Mol Cells       Date:  2019-08-31       Impact factor: 5.034

  5 in total

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