Literature DB >> 2121691

Interleukin-2 receptor beta-chain (p70-75) expressed on leukemic cells from adult T cell leukemia patients.

T Kodaka1, T Uchiyama, T Ishikawa, M Kamio, R Onishi, K Itoh, T Hori, H Uchino, M Tsudo, K Araki.   

Abstract

To determine whether the interleukin-2 receptor (IL-2R) beta-chain (p70-75) is expressed on leukemic cells from patients with adult T cell leukemia (ATL) as well as alpha-chain (p55, Tac), we performed radiolabeled interleukin-2 (IL-2) binding assay, chemical crosslinking of radiolabeled IL-2 and flow cytometric analysis using a newly-developed anti-IL-2R beta-chain antibody. The results showed that leukemic cells from all the 12 ATL patients we examined expressed the IL-2R beta-chain together with the alpha-chain whereas there was no detectable beta-chain expression on unstimulated peripheral blood CD4(+) T cells from healthy volunteers. Southern blot analysis revealed that this abnormal expression was not caused by the structural change of IL-2R beta-chain gene. Though leukemic cells from all ATL patients examined expressed high-affinity IL-2Rs, leukemic cells from only 25% of all ATL patients proliferated in response to IL-2. These results showing abnormal expression of IL-2R beta-chain on leukemic cells from ATL patients (ATL cells) suggest a close association between HTLV-I infection and abnormal beta-chain expression as well as alpha-chain expression.

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Year:  1990        PMID： 2121691      PMCID： PMC5918106          DOI： 10.1111/j.1349-7006.1990.tb02665.x

Source DB:  PubMed          Journal:  Jpn J Cancer Res        ISSN： 0910-5050


  26 in total

1.  Lack of IL 2-dependent proliferation despite significant expression of high-affinity IL 2 receptor on murine cytolytic T lymphocyte clones late after antigenic stimulation.

Authors:  A M Churilla; V L Braciale
Journal:  J Immunol       Date:  1987-03-01       Impact factor: 5.422

2.  Cross-linking of human T cell receptor proteins: association between the T cell idiotype beta subunit and the T3 glycoprotein heavy subunit.

Authors:  M B Brenner; I S Trowbridge; J L Strominger
Journal:  Cell       Date:  1985-01       Impact factor: 41.582

3.  A monoclonal antibody (anti-Tac) reactive with activated and functionally mature human T cells. II. Expression of Tac antigen on activated cytotoxic killer T cells, suppressor cells, and on one of two types of helper T cells.

Authors:  T Uchiyama; D L Nelson; T A Fleisher; T A Waldmann
Journal:  J Immunol       Date:  1981-04       Impact factor: 5.422

4.  Interleukin 2 binding molecule distinct from the Tac protein: analysis of its role in formation of high-affinity receptors.

Authors:  R J Robb; C M Rusk; J Yodoi; W C Greene
Journal:  Proc Natl Acad Sci U S A       Date:  1987-04       Impact factor: 11.205

5.  Leukemic cells from some adult T-cell leukemia patients proliferate in response to interleukin-4.

Authors:  T Uchiyama; M Kamio; T Kodaka; S Tamori; S Fukuhara; R Amakawa; H Uchino; K Araki
Journal:  Blood       Date:  1988-10       Impact factor: 22.113

6.  Monoclonal integration of human T-cell leukemia provirus in all primary tumors of adult T-cell leukemia suggests causative role of human T-cell leukemia virus in the disease.

Authors:  M Yoshida; M Seiki; K Yamaguchi; K Takatsuki
Journal:  Proc Natl Acad Sci U S A       Date:  1984-04       Impact factor: 11.205

7.  Characteristics of the IL-2 receptor expressed on large granular lymphocytes from patients with abnormally expanded large granular lymphocytes. Implication of a non-Tac IL-2-binding peptide.

Authors:  T Hori; T Uchiyama; R Onishi; M Kamio; H Umadome; S Tamori; T Motoi; T Kodaka; H Uchino
Journal:  J Immunol       Date:  1988-06-15       Impact factor: 5.422

8.  Interleukin-2 receptor (Tac antigen) expressed on adult T cell leukemia cells.

Authors:  T Uchiyama; T Hori; M Tsudo; Y Wano; H Umadome; S Tamori; J Yodoi; M Maeda; H Sawami; H Uchino
Journal:  J Clin Invest       Date:  1985-08       Impact factor: 14.808

9.  Dissociation of interleukin-2-mediated cell proliferation and interleukin-2 receptor upregulation in adult T-cell leukemia cells.

Authors:  T Hori; T Uchiyama; H Umadome; S Tamori; M Tsudo; K Araki; H Uchino
Journal:  Leuk Res       Date:  1986       Impact factor: 3.156

10.  Surface phenotype of Japanese adult T-cell leukemia cells characterized by monoclonal antibodies.

Authors:  T Hattori; T Uchiyama; T Toibana; K Takatsuki; H Uchino
Journal:  Blood       Date:  1981-09       Impact factor: 22.113
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4.  Characterization of mRNA expression of IkappaB alpha and NF-kappaB subfamilies in primary adult T-cell leukemia cells.

Authors:  M Inoue; M Matsuoka; K Yamaguchi; K Takatsuki; M Yoshida
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5.  Enhancing effect of interleukin-2 on production of parathyroid hormone-related protein by adult T-cell leukemia cells.

Authors:  N Mori; K Ohsumi; S Murakami; A Wake; F Shirakawa; I Morimoto; S Oda; S Eto
Journal:  Jpn J Cancer Res       Date:  1993-04
  5 in total

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