| Literature DB >> 21216235 |
Ying Pei1, Zhen-Ping Chen, Huai-Qiang Ju, Masaaki Komatsu, Yu-hua Ji, Ge Liu, Chao-wan Guo, Ying-Jun Zhang, Chong-Ren Yang, Yi-Fei Wang, Kaio Kitazato.
Abstract
Pentagalloylglucose (PGG) is a natural polyphenolic compound with broad-spectrum anti-viral activity, however, the mechanisms underlying anti-viral activity remain undefined. In this study, we investigated the effects of PGG on anti-viral activity against Herpes simplex virus type 1 (HSV-1) associated with autophagy. We found that the PGG anti-HSV-1 activity was impaired significantly in MEF-atg7-/- cells (autophagy-defective cells) derived from an atg7-/- knockout mouse. Transmission electron microscopy revealed that PGG-induced autophagosomes engulfed HSV-1 virions. The mTOR signaling pathway, an essential pathway for the regulation of autophagy, was found to be suppressed following PGG treatment. Data presented in this report demonstrated for the first time that autophagy induced following PGG treatment contributed to its anti-HSV activity in vitro.Entities:
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Year: 2011 PMID： 21216235 DOI： 10.1016/j.bbrc.2011.01.006
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575