Literature DB >> 21215627

Biological evaluation of KRIBB3 analogs as a microtubule polymerization inhibitor.

Sangku Lee1, Jae Nyoung Kim, Hyeong Kyu Lee, Kab Seog Yoon, Ki Deok Shin, Byoung-Mog Kwon, Dong Cho Han.   

Abstract

A series of KRIBB3 analogs were synthesized by modifying substituents at aryl moieties of KRIBB3 for examining structure-activity relationships, and their inhibitory activities on microtubule polymerization were evaluated. The presence of free phenolic hydrogens in aryl moieties of KRIBB3 analogs plays an important role in inhibition of microtubule polymerization.
Copyright © 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 21215627     DOI： 10.1016/j.bmcl.2010.12.044

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  4 in total

1.  Synthesis and evaluation of 1,5-disubstituted tetrazoles as rigid analogues of combretastatin A-4 with potent antiproliferative and antitumor activity.

Authors:  Romeo Romagnoli; Pier Giovanni Baraldi; Maria Kimatrai Salvador; Delia Preti; Mojgan Aghazadeh Tabrizi; Andrea Brancale; Xian-Hua Fu; Jun Li; Su-Zhan Zhang; Ernest Hamel; Roberta Bortolozzi; Giuseppe Basso; Giampietro Viola
Journal:  J Med Chem       Date:  2011-12-21       Impact factor: 7.446

2.  Correlation of hydrogen-bonding propensity and anticancer profile of tetrazole-tethered combretastatin analogues.

Authors:  Ganesh S Jedhe; Debasish Paul; Rajesh G Gonnade; Manas K Santra; Ernest Hamel; Tam Luong Nguyen; Gangadhar J Sanjayan
Journal:  Bioorg Med Chem Lett       Date:  2013-06-12       Impact factor: 2.823

3.  Synthesis of novel indole-isoxazole hybrids and evaluation of their cytotoxic activities on hepatocellular carcinoma cell lines.

Authors:  Mohammed Hawash; Deniz Cansen Kahraman; Sezen Guntekin Ergun; Rengul Cetin-Atalay; Sultan Nacak Baytas
Journal:  BMC Chem       Date:  2021-12-20

4.  Pyrrolo[2',3':3,4]cyclohepta[1,2-d][1,2]oxazoles, a New Class of Antimitotic Agents Active against Multiple Malignant Cell Types.

Authors:  Virginia Spanò; Roberta Rocca; Marilia Barreca; Daniele Giallombardo; Alessandra Montalbano; Anna Carbone; Maria Valeria Raimondi; Eugenio Gaudio; Roberta Bortolozzi; Ruoli Bai; Pierfrancesco Tassone; Stefano Alcaro; Ernest Hamel; Giampietro Viola; Francesco Bertoni; Paola Barraja
Journal:  J Med Chem       Date:  2020-10-11       Impact factor: 7.446
  4 in total

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