| Literature DB >> 21215465 |
Erdem Tüzün1, Murat Kürtüncü, Recai Türkoğlu, Sema Içöz, Münevver Pehlivan, Omer Birişik, Mefküre Eraksoy, Gulsen Akman-Demir.
Abstract
The complement system is essential in the pathogenesis of inflammatory central nervous system disorders. To investigate the involvement of complement pathways in neuromyelitis optica (NMO), levels of breakdown products for classical (C4d), alternative (FBb) and common (sC5b-9) pathways were measured in the sera of 28 NMO and control patients (30 Behçet's disease (BD), 29 multiple sclerosis (MS)) and 31 healthy controls by ELISA. Classical and/or alternative pathway consumption was enhanced in NMO and BD patients as compared to MS patients and healthy controls. Our results suggest that NBD and NMO differ from MS by the predominance of complement system involvement.Entities:
Mesh：
Year: 2011 PMID： 21215465 DOI： 10.1016/j.jneuroim.2010.11.010
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478