| Literature DB >> 21214637 |
Maria Cristina Gagliardi1, Stefania Starnino, Raffaela Teloni, Sabrina Mariotti, Ivano Dal Conte, Aldo Di Carlo, Paola Stefanelli.
Abstract
Neisseria gonorrhoeae is the etiological agent of gonorrhoea, an infectious disease characterized by acute inflammation of the urogenital tract with a massive infiltration of neutrophils. Polymorphonuclear leukocyte recruitment is one of the activities of the recently described interleukin-17A (IL-17A); thus, we analyzed the serum concentration of IL-17A, together with IL-23 and interferon-γ (IFN-γ), in 27 patients with gonorrhoea. The concentration of these cytokines in patients' sera was significantly higher than that detected in healthy controls and an inverse correlation was found between the concentrations of IL-17A and IFN-γ. This is the first report showing a significant increase of IL-17A and IL-23 serum levels in patients with gonorrhoea, suggesting new players in the immune response to N. gonorrhoeae. FEMS Immunology & Medical MicrobiologyEntities:
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Year: 2010 PMID： 21214637 DOI： 10.1111/j.1574-695X.2010.00759.x
Source DB: PubMed Journal: FEMS Immunol Med Microbiol ISSN： 0928-8244