Literature DB >> 2121298

Characterization of an acute T lymphoblastic leukemia expressing the gamma/delta T-cell receptor.

M Wilhelm1, H P Tony.   

Abstract

Leukemic cells of a 20 year old patient, suffering from acute lymphoblastic leukemia, were characterized by surface marker and functional analysis. A significant cell population within this type of leukemia expresses concomitantly the CD4 and CD8 antigen on the same cell and might represent a new differentiation stage of T-cells with the gamma/delta receptor. The leukemic cells show a distinct pattern of growth response to mitogens and lymphokines, which might correlate to their differentiation stage. Moreover, a "natural killer"-like activity can be induced in these cells by IL-2.

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Year:  1990        PMID： 2121298     DOI： 10.1007/bf01744133

Source DB:  PubMed          Journal:  Blut        ISSN： 0006-5242


  21 in total

1.  Characterization of the subset of immature thymocytes which can undergo rapid in vitro differentiation.

Authors:  J Nikolić-Zugić; M W Moore; M J Bevan
Journal:  Eur J Immunol       Date:  1989-04       Impact factor: 5.532

Review 2.  Human T-cell precursors: involvement of the IL-2 pathway in the generation of mature T cells.

Authors:  M L Toribio; J M Alonso; A Bárcena; J C Gutiérrez; A de la Hera; M A Marcos; C Márquez; C Martínez
Journal:  Immunol Rev       Date:  1988-08       Impact factor: 12.988

Review 3.  T-cell lineages, repertoire selection and tolerance induction.

Authors:  H R MacDonald; R C Howe; T Pedrazzini; R K Lees; R C Budd; R Schneider; N S Liao; R M Zinkernagel; J A Louis; D H Raulet
Journal:  Immunol Rev       Date:  1988-08       Impact factor: 12.988

4.  Identification of a putative second T-cell receptor.

Authors:  M B Brenner; J McLean; D P Dialynas; J L Strominger; J A Smith; F L Owen; J G Seidman; S Ip; F Rosen; M S Krangel
Journal:  Nature       Date:  1986 Jul 10-16       Impact factor: 49.962

Review 5.  The developmental biology of T lymphocytes.

Authors:  H von Boehmer
Journal:  Annu Rev Immunol       Date:  1988       Impact factor: 28.527

6.  Role of CD2 in activation and cytotoxic function of CD8/Leu-7-positive T cells.

Authors:  J Rüthlein; S P James; W Strober
Journal:  J Immunol       Date:  1988-12-01       Impact factor: 5.422

7.  Intensified therapy in acute lymphoblastic and acute undifferentiated leukemia in adults.

Authors:  D Hoelzer; E Thiel; H Löffler; H Bodenstein; L Plaumann; T Büchner; D Urbanitz; P Koch; H Heimpel; R Engelhardt
Journal:  Blood       Date:  1984-07       Impact factor: 22.113

8.  Activation of CD 4-, CD 8- thymocytes with IL 4 vs IL 1 + IL 2.

Authors:  W C Gause; T Takashi; J D Mountz; F D Finkelman; A D Steinberg
Journal:  J Immunol       Date:  1988-10-01       Impact factor: 5.422

9.  Distinct molecular forms of human T cell receptor gamma/delta detected on viable T cells by a monoclonal antibody.

Authors:  J Borst; J J van Dongen; R L Bolhuis; P J Peters; D A Hafler; E de Vries; R J van de Griend
Journal:  J Exp Med       Date:  1988-05-01       Impact factor: 14.307

10.  Two subsets of human T lymphocytes expressing gamma/delta antigen receptor are identifiable by monoclonal antibodies directed to two distinct molecular forms of the receptor.

Authors:  C Bottino; G Tambussi; S Ferrini; E Ciccone; P Varese; M C Mingari; L Moretta; A Moretta
Journal:  J Exp Med       Date:  1988-08-01       Impact factor: 14.307
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  3 in total

1.  Failure to detect any effect of amalgam restorations on peripheral blood lymphocyte populations.

Authors:  M Wilhelm; P Dünninger; R Rüppel; H P Tony; K Wilms; B Klaiber
Journal:  Clin Investig       Date:  1992-09

2.  Treatment response and outcome of children with T-cell acute lymphoblastic leukemia expressing the gamma-delta T-cell receptor.

Authors:  Ching-Hon Pui; Deqing Pei; Cheng Cheng; Suzanne L Tomchuck; Scarlett N Evans; Hiroto Inaba; Sima Jeha; Susana C Raimondi; John K Choi; Paul G Thomas; Mari Hashitate Dallas
Journal:  Oncoimmunology       Date:  2019-05-17       Impact factor: 8.110

3.  Gamma/delta receptor-expressing T-cell clones from a cutaneous T-cell lymphoma suppress hematopoiesis.

Authors:  M Wilhelm; P Meyer; C Batram; H P Tony; R Dummer; F Nestle; G Burg; K Wilms
Journal:  Ann Hematol       Date:  1992-09       Impact factor: 3.673
  3 in total

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