Literature DB >> 21212834

Lessons from the Niche for Generation and Expansion of Hematopoietic Stem Cells.

Teresa V Bowman1, Leonard I Zon.   

Abstract

Hematopoietic Stem Cells (HSCs) are used clinically to treat human blood-related genetic diseases and leukemias, but the availability of this therapy is constrained by the limiting number of transplantable HSCs. Previous strategies to expand HSCs in vitro resulted in precocious differentiation and reduced transplant efficiency. In vivo analysis of the mechanisms utilized by fetal and adult niches to control HSCs can be mimicked for therapeutic use. This review summarizes the latest research on the in vivo HSC niche and the clinical applications of this knowledge to promote ex vivo expansion and direct de novo generation of HSCs.

Entities:  

Year:  2009        PMID： 21212834      PMCID： PMC3014625          DOI： 10.1016/j.ddstr.2009.06.003

Source DB:  PubMed          Journal:  Drug Discov Today Ther Strateg        ISSN： 1740-6773


  40 in total

Review 1.  The journey of developing hematopoietic stem cells.

Authors:  Hanna K A Mikkola; Stuart H Orkin
Journal:  Development       Date:  2006-10       Impact factor: 6.868

Review 2.  Hematopoietic cell development in the zebrafish embryo.

Authors:  Julien Y Bertrand; David Traver
Journal:  Curr Opin Hematol       Date:  2009-07       Impact factor: 3.284

3.  A molecular profile of a hematopoietic stem cell niche.

Authors:  Jason A Hackney; Pierre Charbord; Brian P Brunk; Christian J Stoeckert; Ihor R Lemischka; Kateri A Moore
Journal:  Proc Natl Acad Sci U S A       Date:  2002-09-11       Impact factor: 11.205

4.  Biomechanical forces promote embryonic haematopoiesis.

Authors:  Luigi Adamo; Olaia Naveiras; Pamela L Wenzel; Shannon McKinney-Freeman; Peter J Mack; Jorge Gracia-Sancho; Astrid Suchy-Dicey; Momoko Yoshimoto; M William Lensch; Mervin C Yoder; Guillermo García-Cardeña; George Q Daley
Journal:  Nature       Date:  2009-05-13       Impact factor: 49.962

5.  Hematopoietic stem cell development is dependent on blood flow.

Authors:  Trista E North; Wolfram Goessling; Marian Peeters; Pulin Li; Craig Ceol; Allegra M Lord; Gerhard J Weber; James Harris; Claire C Cutting; Paul Huang; Elaine Dzierzak; Leonard I Zon
Journal:  Cell       Date:  2009-05-15       Impact factor: 41.582

Review 6.  Towards hematopoietic reconstitution from embryonic stem cells: a sanguine future.

Authors:  Shannon L McKinney-Freeman; George Q Daley
Journal:  Curr Opin Hematol       Date:  2007-07       Impact factor: 3.284

7.  Wnt, activin, and BMP signaling regulate distinct stages in the developmental pathway from embryonic stem cells to blood.

Authors:  M Cristina Nostro; Xin Cheng; Gordon M Keller; Paul Gadue
Journal:  Cell Stem Cell       Date:  2008-01-10       Impact factor: 24.633

8.  Transparent adult zebrafish as a tool for in vivo transplantation analysis.

Authors:  Richard Mark White; Anna Sessa; Christopher Burke; Teresa Bowman; Jocelyn LeBlanc; Craig Ceol; Caitlin Bourque; Michael Dovey; Wolfram Goessling; Caroline Erter Burns; Leonard I Zon
Journal:  Cell Stem Cell       Date:  2008-02-07       Impact factor: 24.633

Review 9.  Chemokines in hematopoiesis.

Authors:  Hal E Broxmeyer
Journal:  Curr Opin Hematol       Date:  2008-01       Impact factor: 3.284

10.  Runx1 is required for the endothelial to haematopoietic cell transition but not thereafter.

Authors:  Michael J Chen; Tomomasa Yokomizo; Brandon M Zeigler; Elaine Dzierzak; Nancy A Speck
Journal:  Nature       Date:  2009-01-07       Impact factor: 49.962
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  6 in total

Review 1.  Lung as a Niche for Hematopoietic Progenitors.

Authors:  Isabella Borges; Isadora Sena; Patrick Azevedo; Julia Andreotti; Viviani Almeida; Ana Paiva; Gabryella Santos; Daniel Guerra; Pedro Prazeres; Luiza Lousado Mesquita; Luanny Souto de Barros Silva; Caroline Leonel; Akiva Mintz; Alexander Birbrair
Journal:  Stem Cell Rev Rep       Date:  2017-10       Impact factor: 5.739

2.  Murine foetal liver supports limited detectable expansion of life-long haematopoietic progenitors.

Authors:  Miguel Ganuza; Trent Hall; Jacquelyn Myers; Chris Nevitt; Raúl Sánchez-Lanzas; Ashley Chabot; Juan Ding; Emilia Kooienga; Claire Caprio; David Finkelstein; Guolian Kang; Esther Obeng; Shannon McKinney-Freeman
Journal:  Nat Cell Biol       Date:  2022-10-06       Impact factor: 28.213

3.  Maintenance of hematopoietic stem cells through regulation of Wnt and mTOR pathways.

Authors:  Jian Huang; Michelle Nguyen-McCarty; Elizabeth O Hexner; Gwenn Danet-Desnoyers; Peter S Klein
Journal:  Nat Med       Date:  2012-11-11       Impact factor: 53.440

Review 4.  Hematopoietic stem cell stretches and moves in its bone marrow niche.

Authors:  Walison N Silva; Alinne C Costa; Caroline C Picoli; Beatriz G S Rocha; Gabryella S P Santos; Pedro A C Costa; Parviz Azimnasab-Sorkhabi; Maryam Soltani-Asl; Rodrigo A da Silva; Jaime Henrique Amorim; Rodrigo R Resende; Akiva Mintz; Alexander Birbrair
Journal:  Crit Rev Oncol Hematol       Date:  2021-05-26       Impact factor: 6.625

Review 5.  Concise Review: Hematopoietic Stem Cell Origins: Lessons from Embryogenesis for Improving Regenerative Medicine.

Authors:  Adriana De La Garza; Arpan Sinha; Teresa V Bowman
Journal:  Stem Cells Transl Med       Date:  2016-08-02       Impact factor: 6.940

Review 6.  Peering through zebrafish to understand inherited bone marrow failure syndromes.

Authors:  Usua Oyarbide; Jacek Topczewski; Seth J Corey
Journal:  Haematologica       Date:  2018-12-20       Impact factor: 9.941
  6 in total

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