H C Kluin-Nelemans1, M van Marwijk Kooy2, P J Lugtenburg3, W L J van Putten4, M Luten4, J Oudejans5, G W van Imhoff6. 1. Department of Hematology, University Medical Center Groningen, University of Groningen, Groningen. Electronic address: j.c.kluin@int.umcg.nl. 2. Department of Internal Medicine, Isala klinieken, Zwolle. 3. Department of Hematology. 4. HOVON Data Center, Erasmus University Medical Center, Rotterdam. 5. Department of Pathology, Diakonessenhuis, Utrecht, The Netherlands. 6. Department of Hematology, University Medical Center Groningen, University of Groningen, Groningen.
Abstract
BACKGROUND: The prognosis of T-cell lymphoma is poor. To explore the addition of the monoclonal antibody alemtuzumab, we studied the efficacy and tolerability of an intensified alemtuzumab-chemotherapy combination for aggressive T-cell lymphoma in a phase II study by Dutch-Belgian Hemato-Oncology Group (HOVON). PATIENTS AND METHODS: Patients (≤65 years) with newly diagnosed T-cell lymphoma received eight CHOP cycles (cyclophosphamide, doxorubicin, vincristine, prednisone) 2-weekly, each cycle with three doses of 30 mg alemtuzumab. Prophylaxis consisted of cotrimoxazole, fluconazole and valaciclovir. Cytomegalovirus (CMV) monitoring took place at least every fortnight. RESULTS: Twenty patients from 10 centers, median age 50 years, were included. Eighty-five percent received six or more cycles. The overall response was 90% [12 complete remissions (CRs), 1 CR unconfirmed, 5 partial remissions]. Median duration of follow-up of patients still alive was 29 months (range 19-41 months). Median overall survival (OS) and event-free survival (EFS) were 27 and 10 months, with 55%/27% OS/EFS at 2 years. Adverse events consisted of neutropenic fever (n = 8) and CMV reactivation (n = 7), with one CMV disease. Three patients developed secondary Epstein-Barr virus (EBV)-related lymphoma, all after end of treatment. CONCLUSIONS: Although intensified alemtuzumab-CHOP induces high responses, many patients relapse, and the scheme is associated with serious infection-related adverse events. EBV monitoring after end of treatment is required.
BACKGROUND: The prognosis of T-cell lymphoma is poor. To explore the addition of the monoclonal antibody alemtuzumab, we studied the efficacy and tolerability of an intensified alemtuzumab-chemotherapy combination for aggressive T-cell lymphoma in a phase II study by Dutch-Belgian Hemato-Oncology Group (HOVON). PATIENTS AND METHODS: Patients (≤65 years) with newly diagnosed T-cell lymphoma received eight CHOP cycles (cyclophosphamide, doxorubicin, vincristine, prednisone) 2-weekly, each cycle with three doses of 30 mg alemtuzumab. Prophylaxis consisted of cotrimoxazole, fluconazole and valaciclovir. Cytomegalovirus (CMV) monitoring took place at least every fortnight. RESULTS: Twenty patients from 10 centers, median age 50 years, were included. Eighty-five percent received six or more cycles. The overall response was 90% [12 complete remissions (CRs), 1 CR unconfirmed, 5 partial remissions]. Median duration of follow-up of patients still alive was 29 months (range 19-41 months). Median overall survival (OS) and event-free survival (EFS) were 27 and 10 months, with 55%/27% OS/EFS at 2 years. Adverse events consisted of neutropenic fever (n = 8) and CMV reactivation (n = 7), with one CMV disease. Three patients developed secondary Epstein-Barr virus (EBV)-related lymphoma, all after end of treatment. CONCLUSIONS: Although intensified alemtuzumab-CHOP induces high responses, many patients relapse, and the scheme is associated with serious infection-related adverse events. EBV monitoring after end of treatment is required.
Authors: Pooja Khandelwal; Julia Lawrence; Alexandra H Filipovich; Stella M Davies; Jacob J Bleesing; Michael B Jordan; Parinda Mehta; Sonata Jodele; Michael S Grimley; Ashish Kumar; Kasiani Myers; Rebecca A Marsh Journal: Pediatr Transplant Date: 2013-10-30
Authors: Joseph Roswarski; Mark Roschewski; Christopher Melani; Stefania Pittaluga; Andrea Lucas; Seth M Steinberg; Elaine S Jaffe; Thomas A Waldmann; Wyndham H Wilson Journal: Leuk Lymphoma Date: 2019-01-10
Authors: Pooja Khandelwal; Chie Emoto; Tsuyoshi Fukuda; Alexander A Vinks; Lisa Neumeier; Christopher E Dandoy; Javier El-Bietar; Sharat Chandra; Stella M Davies; Jacob J Bleesing; Michael B Jordan; Parinda A Mehta; Sonata Jodele; Michael S Grimley; Ashish Kumar; Kasiani C Myers; Rebecca A Marsh Journal: Biol Blood Marrow Transplant Date: 2016-09-21 Impact factor: 5.742