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Literature DB >> 21211589

Novel method for non-invasive induction of a middle-ear biofilm in the rat.

Eric J Chaney¹, Cac T Nguyen, Stephen A Boppart.

Abstract

Otitis media and other middle ear diseases are extremely common among all children worldwide. Chronic otitis media is strongly associated with the presence of a bacterial middle ear biofilm, which if left untreated, may result in hearing loss or delays in the development of speech and language. Many animal models and methods used to study the progression of various middle ear diseases exist. However, there are no reported approaches to biofilm induction in which this infectious process can be investigated. Here we report a unique, non-invasive method of biofilm induction in the rat through repeated bacterial inoculations and pressure changes within the ear.

Entities: CellLine Chemical Disease Gene Species

Mesh：

Year: 2011 PMID： 21211589 PMCID： PMC3200228 DOI： 10.1016/j.vaccine.2010.12.076

Source DB: PubMed Journal: Vaccine ISSN： 0264-410X Impact factor: 3.641

27 in total

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11 in total

1. Noninvasive in vivo optical detection of biofilm in the human middle ear.

Authors: Cac T Nguyen; Woonggyu Jung; Jeehyun Kim; Eric J Chaney; Michael Novak; Charles N Stewart; Stephen A Boppart
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Authors: Guillermo L Monroy; Wenzhou Hong; Pawjai Khampang; Ryan G Porter; Michael A Novak; Darold R Spillman; Ronit Barkalifa; Eric J Chaney; Joseph E Kerschner; Stephen A Boppart
Journal: Otolaryngol Head Neck Surg Date: 2018-03-27 Impact factor: 3.497