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Literature DB >> 21210060

Insights from Caenorhabditis elegans on the role of metals in neurodegenerative diseases.

Ebany J Martinez-Finley¹, Daiana Silva Avila, Sudipta Chakraborty, Michael Aschner.

Abstract

Neurodegeneration is characterized by the cell death or loss of structure and/or function of neurons. Many neurodegenerative diseases including Parkinson's disease (PD) and Alzheimer's disease (AD) are the result of neurodegenerative processes. Metals are essential for many life processes, but they are also culpable for several neurodegenerative mechanisms. In this review, we discuss the role of metals in neurodegenerative diseases with emphasis on the utility of Caenorhabditis elegans (C. elegans) genetic models in deciphering mechanisms associated with the etiology of PD and AD.

Entities: Chemical Disease Gene Mutation Species

Mesh：

Substances：
Metals

Year: 2011 PMID： 21210060 PMCID： PMC3172965 DOI： 10.1039/c0mt00064g

Source DB: PubMed Journal: Metallomics ISSN： 1756-5901 Impact factor: 4.526

100 in total

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Authors: Daniela Berg; Moussa B H Youdim
Journal: Top Magn Reson Imaging Date: 2006-02

2. Dopaminergic neurons in the nematode Caenorhabditis elegans.

Authors: J Sulston; M Dew; S Brenner
Journal: J Comp Neurol Date: 1975-09-15 Impact factor: 3.215

Review 3. Manganese and its role in Parkinson's disease: from transport to neuropathology.

Authors: Michael Aschner; Keith M Erikson; Elena Herrero Hernández; Elena Herrero Hernández; Ronald Tjalkens
Journal: Neuromolecular Med Date: 2009 Impact factor: 3.843

4. Methylmercury induces acute oxidative stress, altering Nrf2 protein level in primary microglial cells.

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Journal: Toxicol Sci Date: 2010-04-26 Impact factor: 4.849

Review 5. Manganese neurotoxicity: a focus on the neonate.

Authors: Keith M Erikson; Khristy Thompson; Judy Aschner; Michael Aschner
Journal: Pharmacol Ther Date: 2006-09-22 Impact factor: 12.310

6. Hormetic effect of methylmercury on Caenorhabditis elegans.

Authors: Kirsten J Helmcke; Michael Aschner
Journal: Toxicol Appl Pharmacol Date: 2010-08-05 Impact factor: 4.219

Review 7. Manganese neurotoxicity.

Authors: Allison W Dobson; Keith M Erikson; Michael Aschner
Journal: Ann N Y Acad Sci Date: 2004-03 Impact factor: 5.691

8. Neurodegeneration and defective neurotransmission in a Caenorhabditis elegans model of tauopathy.

Authors: Brian C Kraemer; Bin Zhang; James B Leverenz; James H Thomas; John Q Trojanowski; Gerard D Schellenberg
Journal: Proc Natl Acad Sci U S A Date: 2003-07-18 Impact factor: 11.205

9. The expression of the Alzheimer's amyloid precursor protein-like gene is regulated by developmental timing microRNAs and their targets in Caenorhabditis elegans.

Authors: Ryusuke Niwa; Feng Zhou; Chris Li; Frank J Slack
Journal: Dev Biol Date: 2008-01-08 Impact factor: 3.582

10. SMF-1, SMF-2 and SMF-3 DMT1 orthologues regulate and are regulated differentially by manganese levels in C. elegans.

Authors: Catherine Au; Alexandre Benedetto; Joel Anderson; Arnaud Labrousse; Keith Erikson; Jonathan J Ewbank; Michael Aschner
Journal: PLoS One Date: 2009-11-18 Impact factor: 3.240

16 in total

Review 1. Role of manganese in neurodegenerative diseases.

Authors: Aaron B Bowman; Gunnar F Kwakye; Elena Herrero Hernández; Michael Aschner
Journal: J Trace Elem Med Biol Date: 2011-10-01 Impact factor: 3.849

Review 2. Inverse Association Between Serum Uric Acid Levels and Alzheimer's Disease Risk.

Authors: Na Du; Donghua Xu; Xu Hou; Xuejia Song; Cancan Liu; Ying Chen; Yangang Wang; Xin Li
Journal: Mol Neurobiol Date: 2015-06-18 Impact factor: 5.590

3. Application of Fluorescence Microscopy and Behavioral Assays to Demonstrating Neuronal Connectomes and Neurotransmitter Systems in C. elegans.

Authors: Omamuyovwi M Ijomone; Priscila Gubert; Comfort O A Okoh; Alexandre M Varão; Leandro de O Amara; Oritoke M Aluko; Michael Aschner
Journal: Neuromethods Date: 2021-07-24

4. Neurochemistry of lead and manganese.

Authors: Rachel Narehood Austin; Jennifer L Freeman; Tomás R Guilarte
Journal: Metallomics Date: 2016-06-01 Impact factor: 4.526

Review 5. The multiple faces of calcineurin signaling in Caenorhabditis elegans: development, behaviour and aging.

Authors: Jin Il Lee; Sutapa Mukherjee; Kyoung-Hye Yoon; Meenakshi Dwivedi; Jaya Bandyopadhyay
Journal: J Biosci Date: 2013-06 Impact factor: 1.826

6. C. elegans and Neurodegeneration In Caenorhabditis Elegans: Anatomy, Life Cycles and Biological Functions.

Authors: Ebany J Martinez-Finley; Sudipta Chakraborty; Sam Caito; Stephanie Fretham; Michael Aschner
Journal: Adv Med Biol Date: 2012

7. n-butylidenephthalide protects against dopaminergic neuron degeneration and α-synuclein accumulation in Caenorhabditis elegans models of Parkinson's disease.

Authors: Ru-Huei Fu; Horng-Jyh Harn; Shih-Ping Liu; Chang-Shi Chen; Wen-Lin Chang; Yue-Mi Chen; Jing-En Huang; Rong-Jhu Li; Sung-Yu Tsai; Huey-Shan Hung; Woei-Cherng Shyu; Shinn-Zong Lin; Yu-Chi Wang
Journal: PLoS One Date: 2014-01-08 Impact factor: 3.240