Sir,I read the recent publication on A386G polymorphism and infertility by Singh et al. with a great interest.[1] Singh et al. reached the conclusion that “as in the report from Italy and South India, our results illustrate the rarity of this mutation. Apparently, this mutation is of recent origin and/or has poor selective value.”[1]Indeed, the clinical correlation between A386G polymorphism of the DAZL gene and idiopathic male infertility is still a myth. The difference in the report from different countries might be due to many possible reasons. First, the race and ethnic effect might be a probable factor contributing to different clinical correlation. This needs further systematic assessment for clarification. Second, the polymorphism, a genetic phenomenon, might not be detectable in a few studied subjects. A larger study might be needed for the verification of the findings. Third, there might be no direct correlation between studied polymorphism and male fertility in reality. A new bioinformatics technique might be useful for the clarification of the clinical correlation of A386G polymorphism as used for other polymorphisms.[2]