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Literature DB >> 212092

Inhibition of collagen peptidase in HeLa cells and human tumours by compounds including drugs used in cancer therapy.

Abstract

Collagen-peptidase activity in extracts of HeLa cells and human tumours is inactivated by Razoxane (ICRF-159), cyclophosphamide, 5-fluorouracil, thiotepa, aprotinin, EDTA and phenanthroline. As this activity, in association with other enzymes, may contribute to tissue lysis in cancers, chemical intervention may reduce invasiveness and modify the processes of infiltration and metastasis. Accordingly, some drugs used in therapy or for the prevention of metastasis may produce their observed effects by a combination of factors including enzyme inhibition.

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Year: 1978 PMID： 212092 PMCID： PMC2009727 DOI： 10.1038/bjc.1978.206

Source DB: PubMed Journal: Br J Cancer ISSN： 0007-0920 Impact factor: 7.640

15 in total

9. The interaction of alpha2-macroglobulin with proteinases. Binding and inhibition of mammalian collagenases and other metal proteinases.

Authors: Z Werb; M C Burleigh; A J Barrett; P M Starkey
Journal: Biochem J Date: 1974-05 Impact factor: 3.857

10. The natural history of metastasis of syngeneic murine squamous carcinoma and the prognostic implications of primary tumour size and duration of growth.

Authors: L J Peters
Journal: Br J Cancer Date: 1975-09 Impact factor: 7.640

Inhibition of collagen peptidase in HeLa cells and human tumours by compounds including drugs used in cancer therapy.

1. [ON THE QUANTITATIVE DETERMINATION OF COLLAGENASE].

2. AN ELECTRON MICROSCOPIC STUDY OF THE INVASION OF ASCITES TUMOR CELLS INTO THE ABDOMINAL WALL.

3. Hydrolysis of synthetic peptides by collagenase.

4. [Collagenase in cells of highly developed animals].

5. In vitro evidence of neutral collagenase activity in an invasive mammalian tumour.

6. Collagenases in mammalian cells.

7. Tadpole collagenase. Preparation and purification.

8. [The activity of collagenase in the simple solid carcinoma of the breast].

9. The interaction of alpha2-macroglobulin with proteinases. Binding and inhibition of mammalian collagenases and other metal proteinases.

10. The natural history of metastasis of syngeneic murine squamous carcinoma and the prognostic implications of primary tumour size and duration of growth.