Literature DB >> 21209019

Leptin-independent programming of adult body weight and adiposity in mice.

Elizabeth C Cottrell1, Malgorzata S Martin-Gronert, Denise S Fernandez-Twinn, Jian'an Luan, Lindsey M Berends, Susan E Ozanne.   

Abstract

Low birth weight and rapid postnatal weight gain are independent and additive risk factors for the subsequent development of metabolic disease. Despite an abundance of evidence for these associations, mechanistic data are lacking. The hormone leptin has received significant interest as a potential programming factor, because differences in the profile of leptin in early life have been associated with altered susceptibility to obesity. Whether leptin alone is a critical factor for programming obesity has, until now, remained unclear. Using the leptin-deficient ob/ob mouse, we show that low birth weight followed by rapid catch-up growth during lactation (recuperated offspring) leads to a persistent increase in body weight in adult life, both in wild-type and ob/ob animals. Furthermore, recuperated offspring are hyperphagic and epididymal fat pad weights are significantly increased, reflecting greater adiposity. These results show definitively that factors other than leptin are crucial in the programming of energy homeostasis in this model and are powerful enough to alter adiposity in a genetically obese strain.

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Year:  2011        PMID: 21209019      PMCID: PMC3884597          DOI: 10.1210/en.2010-0911

Source DB:  PubMed          Journal:  Endocrinology        ISSN: 0013-7227            Impact factor:   4.736


  34 in total

1.  Postnatal regulation of hypothalamic neuropeptide expression by leptin: implications for energy balance and body weight regulation.

Authors:  R S Ahima; S M Hileman
Journal:  Regul Pept       Date:  2000-08-25

2.  Formation of projection pathways from the arcuate nucleus of the hypothalamus to hypothalamic regions implicated in the neural control of feeding behavior in mice.

Authors:  Sebastien G Bouret; Shin J Draper; Richard B Simerly
Journal:  J Neurosci       Date:  2004-03-17       Impact factor: 6.167

Review 3.  Regulation of fat storage via suppressed thermogenesis: a thrifty phenotype that predisposes individuals with catch-up growth to insulin resistance and obesity.

Authors:  A G Dulloo
Journal:  Horm Res       Date:  2006-04-10

4.  Postnatal leptin surge and regulation of circadian rhythm of leptin by feeding. Implications for energy homeostasis and neuroendocrine function.

Authors:  R S Ahima; D Prabakaran; J S Flier
Journal:  J Clin Invest       Date:  1998-03-01       Impact factor: 14.808

5.  Effects of size at birth and childhood growth on the insulin resistance syndrome in elderly individuals.

Authors:  J G Eriksson; T Forsén; J Tuomilehto; V W V Jaddoe; C Osmond; D J P Barker
Journal:  Diabetologia       Date:  2002-03       Impact factor: 10.122

6.  Genetic typing of the mouse ob mutation by PCR and restriction enzyme analysis.

Authors:  T Hirasawa; T Ohara; S Makino
Journal:  Exp Anim       Date:  1997-01

7.  Neonatal leptin treatment reverses developmental programming.

Authors:  M H Vickers; P D Gluckman; A H Coveny; P L Hofman; W S Cutfield; A Gertler; B H Breier; M Harris
Journal:  Endocrinology       Date:  2005-07-14       Impact factor: 4.736

8.  Identification of body fat mass as a major determinant of metabolic rate in mice.

Authors:  Karl J Kaiyala; Gregory J Morton; Brian G Leroux; Kayoko Ogimoto; Brent Wisse; Michael W Schwartz
Journal:  Diabetes       Date:  2010-04-22       Impact factor: 9.461

9.  Early programming of weight gain in mice prevents the induction of obesity by a highly palatable diet.

Authors:  Susan E Ozanne; Rohan Lewis; Bridget J Jennings; C Nicholas Hales
Journal:  Clin Sci (Lond)       Date:  2004-02       Impact factor: 6.124

10.  Fat mass accumulation during childhood determines insulin sensitivity in early adulthood.

Authors:  R W J Leunissen; P Oosterbeek; L K M Hol; A A Hellingman; T Stijnen; A C S Hokken-Koelega
Journal:  J Clin Endocrinol Metab       Date:  2007-11-27       Impact factor: 5.958

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  11 in total

Review 1.  Influence of pre- and peri-natal nutrition on skeletal acquisition and maintenance.

Authors:  M J Devlin; M L Bouxsein
Journal:  Bone       Date:  2011-06-24       Impact factor: 4.398

Review 2.  Developmental influences on circuits programming susceptibility to obesity.

Authors:  Lori M Zeltser
Journal:  Front Neuroendocrinol       Date:  2015-07-21       Impact factor: 8.606

3.  Birth weight and risk of type 2 diabetes in the black women's health study: does adult BMI play a mediating role?

Authors:  Edward A Ruiz-Narváez; Julie R Palmer; Hanna Gerlovin; Lauren A Wise; Varsha G Vimalananda; James L Rosenzweig; Lynn Rosenberg
Journal:  Diabetes Care       Date:  2014-09       Impact factor: 19.112

4.  Different short-term mild exercise modalities lead to differential effects on body composition in healthy prepubertal male rats.

Authors:  D M Sontam; M H Vickers; J M O'Sullivan; M Watson; E C Firth
Journal:  Biomed Res Int       Date:  2015-01-28       Impact factor: 3.411

5.  Zinc oxide nanoparticle-induced atherosclerotic alterations in vitro and in vivo.

Authors:  Zhen Yan; Wenjun Wang; Yongjun Wu; Wei Wang; Bing Li; Ning Liang; Weidong Wu
Journal:  Int J Nanomedicine       Date:  2017-06-13

6.  Programming of mouse obesity by maternal exposure to concentrated ambient fine particles.

Authors:  Minjie Chen; Xiaoke Wang; Ziying Hu; Huifen Zhou; Yanyi Xu; Lianglin Qiu; Xiaobo Qin; Yuhao Zhang; Zhekang Ying
Journal:  Part Fibre Toxicol       Date:  2017-06-23       Impact factor: 9.400

7.  Catch-up growth following intra-uterine growth-restriction programmes an insulin-resistant phenotype in adipose tissue.

Authors:  L M Berends; D S Fernandez-Twinn; M S Martin-Gronert; R L Cripps; S E Ozanne
Journal:  Int J Obes (Lond)       Date:  2012-12-11       Impact factor: 5.095

8.  5-HT2A and 5-HT2C receptors as hypothalamic targets of developmental programming in male rats.

Authors:  Malgorzata S Martin-Gronert; Claire J Stocker; Edward T Wargent; Roselle L Cripps; Alastair S Garfield; Zorica Jovanovic; Giuseppe D'Agostino; Giles S H Yeo; Michael A Cawthorne; Jonathan R S Arch; Lora K Heisler; Susan E Ozanne
Journal:  Dis Model Mech       Date:  2016-01-14       Impact factor: 5.758

9.  Long-lived weight-reduced αMUPA mice show higher and longer maternal-dependent postnatal leptin surge.

Authors:  Mariel Pinsky; Maayan Rauch; Atallah Abbas; Adi Sharabi-Nov; Snait Tamir; Roee Gutman
Journal:  PLoS One       Date:  2017-11-30       Impact factor: 3.240

Review 10.  Experimental Models of Maternal Obesity and Neuroendocrine Programming of Metabolic Disorders in Offspring.

Authors:  Clare M Reynolds; Stephanie A Segovia; Mark H Vickers
Journal:  Front Endocrinol (Lausanne)       Date:  2017-09-25       Impact factor: 5.555

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