Literature DB >> 21208896

Systemic inflammation and fracture healing.

Okan Bastian1, Janesh Pillay, Jacqueline Alblas, Luke Leenen, Leo Koenderman, Taco Blokhuis.   

Abstract

Apart from their pivotal role in the host defense against pathogens, leukocytes are also essential for bone repair, as fracture healing is initiated and directed by a physiological inflammatory response. Leukocytes infiltrate the fracture hematoma and produce several growth and differentiation factors that regulate essential downstream processes of fracture healing. Systemic inflammation alters the numbers and properties of circulating leukocytes, and we hypothesize that these changes are maintained in tissue leukocytes and will lead to impairment of fracture healing after major trauma. The underlying mechanisms will be discussed in this review.

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Year:  2011        PMID： 21208896     DOI： 10.1189/jlb.0810446

Source DB:  PubMed          Journal:  J Leukoc Biol        ISSN： 0741-5400            Impact factor:   4.962


  55 in total

1.  Fracture initiates systemic inflammatory response syndrome through recruiting polymorphonuclear leucocytes.

Authors:  Haipeng Li; Jia Liu; Jianhua Yao; Jianfeng Zhong; Lei Guo; Tiansheng Sun
Journal:  Immunol Res       Date:  2016-08       Impact factor: 2.829

2.  IL-12p40 impairs mesenchymal stem cell-mediated bone regeneration via CD4+ T cells.

Authors:  Jiajia Xu; Yiyun Wang; Jing Li; Xudong Zhang; Yiyun Geng; Yan Huang; Kerong Dai; Xiaoling Zhang
Journal:  Cell Death Differ       Date:  2016-07-29       Impact factor: 15.828

3.  CORR Insights®: Severe Hemorrhagic Shock Leads to a Delayed Fracture Healing and Decreased Bone Callus Strength in a Mouse Model.

Authors:  Hans-Christoph Pape
Journal:  Clin Orthop Relat Res       Date:  2018-04       Impact factor: 4.176

4.  LIPUS vs. reaming in non-union treatment: Cytokine expression course as a tool for evaluation and differentiation of non-union therapy.

Authors:  Julian Doll; Arash Moghaddam; Volker Daniel; Bahram Biglari; Raban Heller; Gerhard Schmidmaier; Tim Friedrich Raven
Journal:  J Orthop       Date:  2019-08-13

Review 5.  Fracture healing under healthy and inflammatory conditions.

Authors:  Lutz Claes; Stefan Recknagel; Anita Ignatius
Journal:  Nat Rev Rheumatol       Date:  2012-01-31       Impact factor: 20.543

Review 6.  Mesenchymal stem cell-macrophage crosstalk and bone healing.

Authors:  Jukka Pajarinen; Tzuhua Lin; Emmanuel Gibon; Yusuke Kohno; Masahiro Maruyama; Karthik Nathan; Laura Lu; Zhenyu Yao; Stuart B Goodman
Journal:  Biomaterials       Date:  2018-01-02       Impact factor: 12.479

Review 7.  Inflammation, fracture and bone repair.

Authors:  Florence Loi; Luis A Córdova; Jukka Pajarinen; Tzu-hua Lin; Zhenyu Yao; Stuart B Goodman
Journal:  Bone       Date:  2016-03-02       Impact factor: 4.398

8.  Human immune cells' behavior and survival under bioenergetically restricted conditions in an in vitro fracture hematoma model.

Authors:  Paula Hoff; Patrick Maschmeyer; Timo Gaber; Tabea Schütze; Tobias Raue; Katharina Schmidt-Bleek; René Dziurla; Saskia Schellmann; Ferenz Leonard Lohanatha; Eric Röhner; Andrea Ode; Gerd-Rüdiger Burmester; Georg N Duda; Carsten Perka; Frank Buttgereit
Journal:  Cell Mol Immunol       Date:  2013-02-11       Impact factor: 11.530

9.  NF-κB inhibits osteogenic differentiation of mesenchymal stem cells by promoting β-catenin degradation.

Authors:  Jia Chang; Fei Liu; Min Lee; Benjamin Wu; Kang Ting; Janette N Zara; Chia Soo; Khalid Al Hezaimi; Weiping Zou; Xiaohong Chen; David J Mooney; Cun-Yu Wang
Journal:  Proc Natl Acad Sci U S A       Date:  2013-05-20       Impact factor: 11.205

10.  Intercellular adhesion molecule-1 inhibits osteogenic differentiation of mesenchymal stem cells and impairs bio-scaffold-mediated bone regeneration in vivo.

Authors:  Fen-Fen Xu; Heng Zhu; Xi-Mei Li; Fei Yang; Ji-De Chen; Bo Tang; Hong-Guang Sun; Ya-Nan Chu; Rong-Xiu Zheng; Yuan-Lin Liu; Li-Sheng Wang; Yi Zhang
Journal:  Tissue Eng Part A       Date:  2014-06-05       Impact factor: 3.845
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