Literature DB >> 2120889

Hypothyroidism in patients with thalassemia syndromes.

S Magro1, P Puzzonia, C Consarino, M C Galati, S Morgione, D Porcelli, S Grimaldi, D Tancrè, V Arcuri, V De Santis.   

Abstract

Sixty transfusion-dependent thalassemic patients were studied by simultaneous measurement of circulating thyroid hormones, basal thyroid-stimulating hormone (TSH) and TSH response to thyrotropin-releasing hormone with the aim of evaluating the frequency of hypothyroidism in such patients, and the relationship between hypothyroidism and compliance with treatment and iron overload. Thyroid failure was present in 31 of the 60 patients. A correlation was found between impairment of thyroid functions, duration of chronic hypoxia and the activities of various transaminases. The results of this study emphasize the importance of early evaluation of thyroid function in thalassemic patients and suggest that anemia and hypoxia may potentiate the toxicity of iron deposition in endocrine glands.

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Year:  1990        PMID： 2120889     DOI： 10.1159/000205032

Source DB:  PubMed          Journal:  Acta Haematol        ISSN： 0001-5792            Impact factor:   2.195


  8 in total

1.  High prevalence of thyroid dysfunction in adult patients with beta-thalassemia major submitted to amiodarone treatment.

Authors:  S Mariotti; A Loviselli; S Murenu; F Sau; L Valentino; A Mandas; S Vacquer; E Martino; A Balestrieri; M E Lai
Journal:  J Endocrinol Invest       Date:  1999-01       Impact factor: 4.256

2.  Endocrine and metabolic disorders in β-thalassemiamajor patients.

Authors:  Fatemeh Saffari; Abolfazl Mahyar; Shabnam Jalilolgadr
Journal:  Caspian J Intern Med       Date:  2012

Review 3.  Growth and endocrine function in thalassemia major in childhood and adolescence.

Authors:  M Delvecchio; L Cavallo
Journal:  J Endocrinol Invest       Date:  2010-01       Impact factor: 4.256

4.  Impact of genotype on endocrinal complications in β-thalassemia patients.

Authors:  Ahmed Al-Akhras; Mohamed Badr; Usama El-Safy; Elisabeth Kohne; Tamer Hassan; Hadeel Abdelrahman; Mohamed Mourad; Joaquin Brintrup; Marwa Zakaria
Journal:  Biomed Rep       Date:  2016-04-04

5.  Evaluation of serum levels in T3, T4 and TSH in beta-thalassemic patients referred to the Abuzar hospital in Ahwaz.

Authors:  Zari Tahannejad Asad; Majid Ghazanfari; Seyyed Nima Naleini; Azam Sabagh; Wesam Kooti
Journal:  Electron Physician       Date:  2016-07-25

6.  Growth and endocrine disorders in thalassemia: The international network on endocrine complications in thalassemia (I-CET) position statement and guidelines.

Authors:  Vincenzo De Sanctis; Ashraf T Soliman; Heba Elsedfy; Nicos Skordis; Christos Kattamis; Michael Angastiniotis; Mehran Karimi; Mohd Abdel Daem Mohd Yassin; Ahmed El Awwa; Iva Stoeva; Giuseppe Raiola; Maria Concetta Galati; Elsaid M Bedair; Bernadette Fiscina; Mohamed El Kholy
Journal:  Indian J Endocrinol Metab       Date:  2013-01

7.  Metabolic and endocrinologic complications in beta-thalassemia major: a multicenter study in Tehran.

Authors:  Alireza Abdollah Shamshirsaz; Mir Reza Bekheirnia; Mohammad Kamgar; Nima Pourzahedgilani; Navid Bouzari; Mohammadreza Habibzadeh; Reza Hashemi; Amirhooshang Abdollah Shamshirsaz; Shahriar Aghakhani; Hooman Homayoun; Bagher Larijani
Journal:  BMC Endocr Disord       Date:  2003-08-12       Impact factor: 2.763

8.  Growth and Endocrine Function in Tunisian Thalassemia Major Patients.

Authors:  Naouel Guirat Dhouib; Monia Ben Khaled; Monia Ouederni; Habib Besbes; Ridha Kouki; Fethi Mellouli; Mohamed Bejaoui
Journal:  Mediterr J Hematol Infect Dis       Date:  2018-05-01       Impact factor: 2.576
  8 in total

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