OBJECTIVE: To examine the quality of reporting and predictors of reporting in randomized clinical trials (RCTs) of herbal medicine interventions. STUDY DESIGN AND SETTING: We searched Medical Literature Analysis and Retrieval System Online, Excerpta Medica Database, and Academy of Microscope Enhanced Dentistry up to December 2007 for any English language RCT of 11 commonly used herbal medicine interventions. Two individuals separately and independently assessed all trials using the Consolidated Standards of Reporting Trials (CONSORT) checklist for herbal medicines interventions. We randomly selected 100 of these trials, extracted a set of potential predictor variables identified through a literature search and consultation with experts, and performed a conceptually driven stepwise elimination regression analyses for predictor variables. RESULTS: The 406 trials reported on average 38% of the information suggested in the checklist. Regression analyses revealed better overall reporting in trials with a participant flow diagram (P=0.008), those of Panax quinquefolius (P=0.018), and those published in more recent years (P=0.02). CONCLUSION: Our results indicate that RCTs of herbal medicine interventions frequently do not report important characteristics of the intervention. Trialists should refer to the CONSORT for herbal medicines when reporting their trials.
OBJECTIVE: To examine the quality of reporting and predictors of reporting in randomized clinical trials (RCTs) of herbal medicine interventions. STUDY DESIGN AND SETTING: We searched Medical Literature Analysis and Retrieval System Online, Excerpta Medica Database, and Academy of Microscope Enhanced Dentistry up to December 2007 for any English language RCT of 11 commonly used herbal medicine interventions. Two individuals separately and independently assessed all trials using the Consolidated Standards of Reporting Trials (CONSORT) checklist for herbal medicines interventions. We randomly selected 100 of these trials, extracted a set of potential predictor variables identified through a literature search and consultation with experts, and performed a conceptually driven stepwise elimination regression analyses for predictor variables. RESULTS: The 406 trials reported on average 38% of the information suggested in the checklist. Regression analyses revealed better overall reporting in trials with a participant flow diagram (P=0.008), those of Panax quinquefolius (P=0.018), and those published in more recent years (P=0.02). CONCLUSION: Our results indicate that RCTs of herbal medicine interventions frequently do not report important characteristics of the intervention. Trialists should refer to the CONSORT for herbal medicines when reporting their trials.
Authors: Barbara C Sorkin; Adam J Kuszak; Gregory Bloss; Naomi K Fukagawa; Freddie Ann Hoffman; Mahtab Jafari; Bruce Barrett; Paula N Brown; Frederic D Bushman; Steven J Casper; Floyd H Chilton; Christopher S Coffey; Mario G Ferruzzi; D Craig Hopp; Mairead Kiely; Daniel Lakens; John B MacMillan; David O Meltzer; Marco Pahor; Jeffrey Paul; Kathleen Pritchett-Corning; Sara K Quinney; Barbara Rehermann; Kenneth D R Setchell; Nisha S Sipes; Jacqueline M Stephens; D Lansing Taylor; Hervé Tiriac; Michael A Walters; Dan Xi; Giovanna Zappalá; Guido F Pauli Journal: FASEB J Date: 2019-12-10 Impact factor: 5.834
Authors: Titilayo Tatiana Agbadjé; Paula Riganti; Évèhouénou Lionel Adisso; Rhéda Adekpedjou; Alexandrine Boucher; Andressa Teoli Nunciaroni; Juan Victor Ariel Franco; Maria Victoria Ruiz Yanzi; France Légaré Journal: PLoS One Date: 2022-03-16 Impact factor: 3.240