| Literature DB >> 21208614 |
Christophe Audouard1, Elisabeth Christians.
Abstract
To study the role of Hsp90β1, an endoplasmic chaperone, we have built a conditional knockout by crossing Hsp90β1(flox/flox) with the Vasa-Cre transgenic line. Spermatozoa deficient in Hsp90β1 could not naturally fertilize oocytes and exhibited large and globular heads with abnormal intermediate pieces, a phenotype reminiscent of human globozoospermia.Entities:
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Year: 2011 PMID： 21208614 DOI： 10.1016/j.fertnstert.2010.12.006
Source DB: PubMed Journal: Fertil Steril ISSN： 0015-0282 Impact factor: 7.329