AIM: To investigate the roles of serotonergic neurons in dorsal raphe nuclei (DRN) in sleep. METHODS: Stereotaxic, microinjection and polysomnography (PSG) were used in the experiment. RESULTS: Microinjection of L-glutanate (L-Glu) into the DRN decreased slow wave sleep (SWS) and paradoxical sleep (PS), and increased wake (W). Microinjection of kainic acid (KA) and p-chlorophenylalanine (PCPA) respectively into the DRN, SWS and PS were promoted, and W was reduced. CONCLUSION: Serotonergic neurons in dorsal raphe nuclei involved in the regulation of sleep. Sleep was reduced when the serotonergic neurons were excited, and when the neurons were inhibited. sleep was increased
AIM: To investigate the roles of serotonergic neurons in dorsal raphe nuclei (DRN) in sleep. METHODS: Stereotaxic, microinjection and polysomnography (PSG) were used in the experiment. RESULTS: Microinjection of L-glutanate (L-Glu) into the DRN decreased slow wave sleep (SWS) and paradoxical sleep (PS), and increased wake (W). Microinjection of kainic acid (KA) and p-chlorophenylalanine (PCPA) respectively into the DRN, SWS and PS were promoted, and W was reduced. CONCLUSION: Serotonergic neurons in dorsal raphe nuclei involved in the regulation of sleep. Sleep was reduced when the serotonergic neurons were excited, and when the neurons were inhibited. sleep was increased
Authors: Jun Oh; Cathrine Petersen; Christine M Walsh; Jackson C Bittencourt; Thomas C Neylan; Lea T Grinberg Journal: Mol Psychiatry Date: 2018-10-30 Impact factor: 15.992