Literature DB >> 21207119

Is gastrointestinal dysfunction induced by gastric cancer peritoneal metastasis relevant to impairment of interstitial cells of Cajal?

Hongqun Zheng1, Yan He, Jinxue Tong, Lingyu Sun, Dongdong Yang, Huaming Li, Ning Ao, Xiaoming Jin, Qifan Zhang.   

Abstract

Although impaired gastrointestinal motility from gastric cancer peritoneal metastasis (GCPM) causes extraordinary pain, its cause is unclear. Interstitial cells of Cajal (ICC) are apparently pacemaker cells, and their loss could cause motor dysfunction. In this study, we developed a mouse model for GCPM, and investigated electrophysiological changes in the small intestine and attendant changes in ICC. We found decreased ICC and disrupted electrical rhythm in the model. Pathologic ICC changes were well described. Cancer peritoneal metastasis may impair intestinal myoelectrical activity by damaging ICC and ICC networks. Interstitial cells of Cajal will be a target of palliative treatment and merit further study.

Entities:  

Mesh：

Year:  2011        PMID： 21207119     DOI： 10.1007/s10585-010-9371-7

Source DB:  PubMed          Journal:  Clin Exp Metastasis        ISSN： 0262-0898            Impact factor:   5.150


  33 in total

Review 1.  Guide to the identification of interstitial cells of Cajal.

Authors:  M S Faussone-Pellegrini; L Thuneberg
Journal:  Microsc Res Tech       Date:  1999-11-15       Impact factor: 2.769

2.  In vivo gastric and intestinal slow waves in W/WV mice.

Authors:  Xiaohua Hou; Jieyun Yin; Jinsong Liu; Pankaj J Pasricha; J D Z Chen
Journal:  Dig Dis Sci       Date:  2005-07       Impact factor: 3.199

3.  Loss of intramuscular and submuscular interstitial cells of Cajal and associated enteric nerves is related to decreased gastric emptying in streptozotocin-induced diabetes.

Authors:  X-Y Wang; J D Huizinga; J Diamond; L W C Liu
Journal:  Neurogastroenterol Motil       Date:  2009-06-30       Impact factor: 3.598

4.  Development of interstitial cells of Cajal in a full-term infant without an enteric nervous system.

Authors:  J D Huizinga; I Berezin; K Sircar; B Hewlett; G Donnelly; P Bercik; C Ross; T Algoufi; P Fitzgerald; T Der; R H Riddell; S M Collins; K Jacobson
Journal:  Gastroenterology       Date:  2001-02       Impact factor: 22.682

5.  Phenotypic alteration of interstitial cells of Cajal in idiopathic sigmoid megacolon.

Authors:  Yasushi Adachi; Yoshifumi Ishii; Mitsuru Yoshimoto; Yukinari Yoshida; Takao Endo; Hiroyuki Yamamoto; Hirofumi Akashi; Kohzoh Imai; Yasuhisa Shinomura; Yasuo Kato
Journal:  J Gastroenterol       Date:  2008-08-17       Impact factor: 7.527

6.  Mutation of the proto-oncogene c-kit blocks development of interstitial cells and electrical rhythmicity in murine intestine.

Authors:  S M Ward; A J Burns; S Torihashi; K M Sanders
Journal:  J Physiol       Date:  1994-10-01       Impact factor: 5.182

Review 7.  Interstitial cells of Cajal in diabetic gastroenteropathy.

Authors:  T Ordög
Journal:  Neurogastroenterol Motil       Date:  2008-01       Impact factor: 3.598

8.  Assessing interstitial cells of Cajal in slow transit constipation using CD117 is a useful diagnostic test.

Authors:  Lai Mun Wang; Marie McNally; John Hyland; Kieran Sheahan
Journal:  Am J Surg Pathol       Date:  2008-07       Impact factor: 6.394

9.  Interstitial cells of Cajal reduce in number in recto-sigmoid Hirschsprung's disease and total colonic aganglionosis.

Authors:  Hefeng Wang; Yuhua Zhang; Wei Liu; Rongde Wu; Xinguo Chen; Linuan Gu; Bin Wei; Yingmao Gao
Journal:  Neurosci Lett       Date:  2009-01-13       Impact factor: 3.046

10.  Interstitial cells of Cajal generate a rhythmic pacemaker current.

Authors:  L Thomsen; T L Robinson; J C Lee; L A Farraway; M J Hughes; D W Andrews; J D Huizinga
Journal:  Nat Med       Date:  1998-07       Impact factor: 53.440
View more
  4 in total

1.  The effect of SCF and ouabain on small intestinal motility dysfunction induced by gastric cancer peritoneal metastasis.

Authors:  Dan Kong; Jing Li; Baoshan Zhao; Bairong Xia; Lei Zhang; Yan He; Xiuli Wang; Lei Gao; Yufu Wang; Xiaoming Jin; Ge Lou
Journal:  Clin Exp Metastasis       Date:  2015-02-19       Impact factor: 5.150

2.  The impact of inflammatory cells in malignant ascites on small intestinal ICCs' morphology and function.

Authors:  Jing Li; Dan Kong; Yan He; Xiuli Wang; Lei Gao; Jiade Li; Meisi Yan; Duanyang Liu; Yufu Wang; Lei Zhang; Xiaoming Jin
Journal:  J Cell Mol Med       Date:  2015-06-18       Impact factor: 5.310

3.  Association between hyperpolarization-activated channel in interstitial cells of Cajal and gastrointestinal dysmotility induced by malignant ascites.

Authors:  Tieyun Guo; Jiade Li; Jing Li; Dan Kong; Chunli Bi; Zheng He; Dai Tang; Xiaoming Jin; Lianhong Jin
Journal:  Oncol Lett       Date:  2017-01-25       Impact factor: 2.967

4.  Delivery of Mesenchymal Stem Cells from Gelatin-Alginate Hydrogels to Stomach Lumen for Treatment of Gastroparesis.

Authors:  Binata Joddar; Nishat Tasnim; Vikram Thakur; Alok Kumar; Richard W McCallum; Munmun Chattopadhyay
Journal:  Bioengineering (Basel)       Date:  2018-02-07
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.