Study of spirometry and airway reactivity in patients on disulfirm for treatment of alcoholism.

The aim of our study was to examine the short term effect ofdisulfiram on pulmonary functions of alcohol dependent subjects, who were chronic smokers J/Ve compared FEV1 % values on spirometry and airway reactivity to histamine challenge in alcohol dependent subjects at baseline and after 2 weeks of treatment with disulfiram. Disulfiram did not significantly alter FEVI values and airway reactivity during the treatment period and can thus be used safely in alcohol dependent subjects who are current smokers.