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Literature DB >> 21204003

Forgetting and small G protein Rac.

Abstract

It is far from understood why we forget things that are known to us seconds ago. Emerging evidence emphasizes that small G protein Rac could be a key to understanding this type of rapid early memory forgetting. This current perspective article will first review these studies and then discuss their implications for the internal processes underlying forgetting.

Entities: Gene

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Year: 2010 PMID： 21204003 PMCID： PMC4875324 DOI： 10.1007/s13238-010-0077-z

Source DB: PubMed Journal: Protein Cell ISSN： 1674-800X Impact factor: 14.870

22 in total

Review 1. Rho GTPases in cell biology.

Authors: Sandrine Etienne-Manneville; Alan Hall
Journal: Nature Date: 2002-12-12 Impact factor: 49.962

2. Hippocampal LTP is accompanied by enhanced F-actin content within the dendritic spine that is essential for late LTP maintenance in vivo.

Authors: Yugo Fukazawa; Yoshito Saitoh; Fumiko Ozawa; Yasuhiko Ohta; Kensaku Mizuno; Kaoru Inokuchi
Journal: Neuron Date: 2003-05-08 Impact factor: 17.173

Review 3. Structural plasticity and memory.

Authors: Raphael Lamprecht; Joseph LeDoux
Journal: Nat Rev Neurosci Date: 2004-01 Impact factor: 34.870

4. Abnormal spine morphology and enhanced LTP in LIMK-1 knockout mice.

Authors: Yanghong Meng; Yu Zhang; Vitali Tregoubov; Christopher Janus; Luis Cruz; Mike Jackson; Wei Yang Lu; John F MacDonald; Jay Y Wang; Douglas L Falls; Zhengping Jia
Journal: Neuron Date: 2002-07-03 Impact factor: 17.173

5. Rapid and persistent modulation of actin dynamics regulates postsynaptic reorganization underlying bidirectional plasticity.

Authors: Ken-Ichi Okamoto; Takeharu Nagai; Atsushi Miyawaki; Yasunori Hayashi
Journal: Nat Neurosci Date: 2004-09-07 Impact factor: 24.884

Forgetting and small G protein Rac.

Review 1. Rho GTPases in cell biology.

2. Hippocampal LTP is accompanied by enhanced F-actin content within the dendritic spine that is essential for late LTP maintenance in vivo.

Review 3. Structural plasticity and memory.

4. Abnormal spine morphology and enhanced LTP in LIMK-1 knockout mice.

5. Rapid and persistent modulation of actin dynamics regulates postsynaptic reorganization underlying bidirectional plasticity.

6. Transient decrease in F-actin may be necessary for translocation of proteins into dendritic spines.

7. Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase.

8. Rho GTPases regulate axon growth through convergent and divergent signaling pathways.

9. Genetic dissection of consolidated memory in Drosophila.

Review 10. The substrates of memory: defects, treatments, and enhancement.

1. Dissecting neural pathways for forgetting in Drosophila olfactory aversive memory.

Review 2. The role of the actin cytoskeleton in regulating Drosophila behavior.

Review 3. Forgetting as a form of adaptive engram cell plasticity.

4. Scribble Scaffolds a Signalosome for Active Forgetting.

5. RhoGAP18B Isoforms Act on Distinct Rho-Family GTPases and Regulate Behavioral Responses to Alcohol via Cofilin.