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Literature DB >> 21203947

Cellular models for disease exploring and drug screening.

Abstract

The biopharmaceutical industry has been greatly promoted by the application of drug and disease models, including both animal and cellular models. In particular, the emergence of induced pluripotent stem cells (iPSC) makes it possible to create a large number of disease-specific cells in vitro. This review introduces the most widely applied models and their specialties.

Mesh：

Year: 2010 PMID： 21203947 PMCID： PMC4875092 DOI： 10.1007/s13238-010-0027-9

Source DB: PubMed Journal: Protein Cell ISSN： 1674-800X Impact factor: 14.870

78 in total

Review 1. A commentary on the use of hepatocytes in drug metabolism studies during drug discovery and development.

Authors: D M Cross; M K Bayliss
Journal: Drug Metab Rev Date: 2000-05 Impact factor: 4.518

Review 2. Embryonic stem cells as an in vitro model for mutagenicity, cytotoxicity and embryotoxicity studies: present state and future prospects.

Authors: J Rohwedel; K Guan; C Hegert; A M Wobus
Journal: Toxicol In Vitro Date: 2001-12 Impact factor: 3.500

Review 3. Human umbilical cord blood-derived mast cells: a unique model for the study of neuro-immuno-endocrine interactions.

Authors: T C Theoharides; D Kempuraj; M Tagen; M Vasiadi; C L Cetrulo
Journal: Stem Cell Rev Date: 2006 Impact factor: 5.739

4. Induced pluripotent stem cells generated without viral integration.

Authors: Matthias Stadtfeld; Masaki Nagaya; Jochen Utikal; Gordon Weir; Konrad Hochedlinger
Journal: Science Date: 2008-09-25 Impact factor: 47.728

Review 5. Immortalization of human preadipocytes.

Authors: Christian Darimont; Katherine Macé
Journal: Biochimie Date: 2003-12 Impact factor: 4.079

6. iPS cells produce viable mice through tetraploid complementation.

Authors: Xiao-yang Zhao; Wei Li; Zhuo Lv; Lei Liu; Man Tong; Tang Hai; Jie Hao; Chang-long Guo; Qing-wen Ma; Liu Wang; Fanyi Zeng; Qi Zhou
Journal: Nature Date: 2009-09-03 Impact factor: 49.962

7. An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer.

Authors: Teresa A Soucy; Peter G Smith; Michael A Milhollen; Allison J Berger; James M Gavin; Sharmila Adhikari; James E Brownell; Kristine E Burke; David P Cardin; Stephen Critchley; Courtney A Cullis; Amanda Doucette; James J Garnsey; Jeffrey L Gaulin; Rachel E Gershman; Anna R Lublinsky; Alice McDonald; Hirotake Mizutani; Usha Narayanan; Edward J Olhava; Stephane Peluso; Mansoureh Rezaei; Michael D Sintchak; Tina Talreja; Michael P Thomas; Tary Traore; Stepan Vyskocil; Gabriel S Weatherhead; Jie Yu; Julie Zhang; Lawrence R Dick; Christopher F Claiborne; Mark Rolfe; Joseph B Bolen; Steven P Langston
Journal: Nature Date: 2009-04-09 Impact factor: 49.962

8. Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts.

Authors: Masato Nakagawa; Michiyo Koyanagi; Koji Tanabe; Kazutoshi Takahashi; Tomoko Ichisaka; Takashi Aoi; Keisuke Okita; Yuji Mochiduki; Nanako Takizawa; Shinya Yamanaka
Journal: Nat Biotechnol Date: 2007-11-30 Impact factor: 54.908

9. Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs.

Authors: Gabsang Lee; Eirini P Papapetrou; Hyesoo Kim; Stuart M Chambers; Mark J Tomishima; Christopher A Fasano; Yosif M Ganat; Jayanthi Menon; Fumiko Shimizu; Agnes Viale; Viviane Tabar; Michel Sadelain; Lorenz Studer
Journal: Nature Date: 2009-08-19 Impact factor: 49.962

Cellular models for disease exploring and drug screening.

Review 1. A commentary on the use of hepatocytes in drug metabolism studies during drug discovery and development.

Review 2. Embryonic stem cells as an in vitro model for mutagenicity, cytotoxicity and embryotoxicity studies: present state and future prospects.

Review 3. Human umbilical cord blood-derived mast cells: a unique model for the study of neuro-immuno-endocrine interactions.

4. Induced pluripotent stem cells generated without viral integration.

Review 5. Immortalization of human preadipocytes.

6. iPS cells produce viable mice through tetraploid complementation.

7. An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer.

8. Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts.

9. Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs.

10. Direct cell reprogramming is a stochastic process amenable to acceleration.

1. Induction of pluripotent stem cells from autopsy donor-derived somatic cells.

2. Rapid conversion of human ESCs into mouse ESC-like pluripotent state by optimizing culture conditions.

3. A novel xeno-free and feeder-cell-free system for human pluripotent stem cell culture.

4. In vitro-differentiated neural cell cultures progress towards donor-identical brain tissue.