Aerobic copper/TEMPO-catalyzed oxidation of primary alcohols to aldehydes using a microbubble strategy to increase gas concentration in liquid phase reactions.

An efficient method for the synthesis of aldehydes was achieved by using air-microbubble techniques in aerobic copper/TEMPO-catalyzed oxidation of primary alcohols. Use of air-microbubbles to improve gas absorption into liquid phase is proven to be highly beneficial for gas/liquid phase reactions.