Literature DB >> 21202575

1-Phenyl-6,7,8,9-hexa-hydro-1H,5H-cyclo-hepta-[1',2':2,3]pyrido[6,5-c]pyrazol-4-amine: a new tacrine analogue.

Lijun Zhang1, Daxin Shi, Jiarong Li, Ling Zhang, Yanqiu Fan.   

Abstract

The title compound, C(17)H(18)N(4), contains a pyrazolopyridine system fused with a seven-membered carbocyclic ring. The pyrazole ring is coplanar with the pyridine ring, while the phenyl ring is twisted by a dihedral angle of 14.38 (14)° with respect to the pyridine ring. The seven-membered ring displays a chair conformation. The packing is stabilized by N-H⋯N hydrogen bonds and N-H⋯π(arene) inter-actions.

Entities:  

Year:  2008        PMID: 21202575      PMCID: PMC2961386          DOI: 10.1107/S1600536808013366

Source DB:  PubMed          Journal:  Acta Crystallogr Sect E Struct Rep Online        ISSN: 1600-5368


  7 in total

1.  9-(2-Fluorobenzyl)-6-(alkylamino)-9H-purines. A new class of anticonvulsant agents.

Authors:  J L Kelley; M P Krochmal; J A Linn; E W McLean; F E Soroko
Journal:  J Med Chem       Date:  1988-05       Impact factor: 7.446

2.  Development and characterization of a new model of tacrine-induced hepatotoxicity: role of the sympathetic nervous system and hypoxia-reoxygenation.

Authors:  R F Stachlewitz; G E Arteel; J A Raleigh; H D Connor; R P Mason; R G Thurman
Journal:  J Pharmacol Exp Ther       Date:  1997-09       Impact factor: 4.030

3.  A short history of SHELX.

Authors:  George M Sheldrick
Journal:  Acta Crystallogr A       Date:  2007-12-21       Impact factor: 2.290

4.  The non-xanthine heterocyclic compound SCH 58261 is a new potent and selective A2a adenosine receptor antagonist.

Authors:  C Zocchi; E Ongini; A Conti; A Monopoli; A Negretti; P G Baraldi; S Dionisotti
Journal:  J Pharmacol Exp Ther       Date:  1996-02       Impact factor: 4.030

5.  Derivatives of the triazoloquinazoline adenosine antagonist (CGS15943) are selective for the human A3 receptor subtype.

Authors:  Y C Kim; X D Ji; K A Jacobson
Journal:  J Med Chem       Date:  1996-10-11       Impact factor: 7.446

6.  Crystal packing mediates enantioselective ligand recognition at the peripheral site of acetylcholinesterase.

Authors:  Haim Haviv; Dawn M Wong; Harry M Greenblatt; Paul R Carlier; Yuan-Ping Pang; Israel Silman; Joel L Sussman
Journal:  J Am Chem Soc       Date:  2005-08-10       Impact factor: 15.419

7.  Safety of tacrine: clinical trials, treatment IND, and postmarketing experience.

Authors:  S I Gracon; M J Knapp; W G Berghoff; M Pierce; R DeJong; S J Lobbestael; J Symons; S L Dombey; F A Luscombe; D Kraemer
Journal:  Alzheimer Dis Assoc Disord       Date:  1998-06       Impact factor: 2.703

  7 in total

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