BACKGROUND AND AIMS: Previous studies indicated that the arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene polymorphisms are associated with risk of coronary heart disease (CHD). However, other studies have yielded contradictory results. This meta-analysis investigated the relationship between variants of arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene and CHD. METHODS: We identified all studies published before January 2010 through computer-based searches of PubMed, EMBASE, Google Scholar databases, and CNKI (Chinese National Knowledge Infrastructure). Data were extracted by two authors and pooled odds ratio (OR) and 95% confidence interval (CI) were calculated. RESULTS: In this meta-analysis, HapA haplotype (rs17222814G-rs10507391T-rs4769874G-rs9551963A) was associated with myocardial infarction (MI) (OR = 1.37, 95% CI: 1.02-1.82). Regarding the HapB haplotype (rs17216473A-rs10507391A- rs9315050A- rs17222842G), there was a significant association with CHD (OR = 1.33, 95% CI: 1.10-1.62). For the rs17222814, rs10507391, rs4769874, rs9551963, rs17216473, rs9315050 and rs9579646 polymorphisms, there were no associations with CHD. For the rs17222842 polymorphism, there was a marginal association with the risk of CHD (OR = 1.17, 95% CI: 1.00-1.36). CONCLUSIONS: In this meta-analysis, the HapB haplotype and rs1722842 polymorphism in ALOX5AP gene were associated with CHD, and the HapA haplotype was associated with risk of MI. The HapB haplotype may be a predictor to the risk of CHD. Copyright Â
BACKGROUND AND AIMS: Previous studies indicated that the arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene polymorphisms are associated with risk of coronary heart disease (CHD). However, other studies have yielded contradictory results. This meta-analysis investigated the relationship between variants of arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene and CHD. METHODS: We identified all studies published before January 2010 through computer-based searches of PubMed, EMBASE, Google Scholar databases, and CNKI (Chinese National Knowledge Infrastructure). Data were extracted by two authors and pooled odds ratio (OR) and 95% confidence interval (CI) were calculated. RESULTS: In this meta-analysis, HapA haplotype (rs17222814G-rs10507391T-rs4769874G-rs9551963A) was associated with myocardial infarction (MI) (OR = 1.37, 95% CI: 1.02-1.82). Regarding the HapB haplotype (rs17216473A-rs10507391A- rs9315050A- rs17222842G), there was a significant association with CHD (OR = 1.33, 95% CI: 1.10-1.62). For the rs17222814, rs10507391, rs4769874, rs9551963, rs17216473, rs9315050 and rs9579646 polymorphisms, there were no associations with CHD. For the rs17222842 polymorphism, there was a marginal association with the risk of CHD (OR = 1.17, 95% CI: 1.00-1.36). CONCLUSIONS: In this meta-analysis, the HapB haplotype and rs1722842 polymorphism in ALOX5AP gene were associated with CHD, and the HapA haplotype was associated with risk of MI. The HapB haplotype may be a predictor to the risk of CHD. Copyright Â
Authors: Sarah E Kleinstein; Laura Heath; Karen W Makar; Elizabeth M Poole; Brenna L Seufert; Martha L Slattery; Liren Xiao; David J Duggan; Li Hsu; Karen Curtin; Lisel Koepl; Jill Muehling; Darin Taverna; Bette J Caan; Christopher S Carlson; John D Potter; Cornelia M Ulrich Journal: Genes Chromosomes Cancer Date: 2013-02-12 Impact factor: 5.006
Authors: Bernhard Winder; Sophia J Kiechl; Nadja M Gruber; Benoît Bernar; Nina Gande; Anna Staudt; Katharina Stock; Christoph Hochmayr; Ralf Geiger; Andrea Griesmacher; Markus Anliker; Stefan Kiechl; Ursula Kiechl-Kohlendorfer; Michael Knoflach Journal: BMC Cardiovasc Disord Date: 2022-01-18 Impact factor: 2.298