CONTEXT & OBJECTIVE: A recent paper by our group reported that regular aerobic exercise during pregnancy led to lower foetal IGF-I and IGF-II concentrations and a modest reduction in offspring birth weight when compared with the offspring of nontraining control participants. Maternal hormonal alterations in response to exercise training may be associated with the regulation of nutrient availability for foetal growth through placental regulation of maternal metabolism. OBJECTIVE: To determine whether the reduction in offspring size was associated with changes in the maternal IGF axis [including placental growth hormone (PGH)], leptin and/or free fatty acids (FFA) in response to aerobic exercise training in the second half of pregnancy. DESIGN AND SETTING: A randomized, controlled trial of exercise in pregnancy. PATIENTS: Eighty-four healthy nulliparous women (mean±SD age 30±4 year, BMI 25·5±4 kg/m(2) ). MEASUREMENTS: Serum samples were drawn at 19 and 35 weeks gestation to determine serum IGF-I, IGF-II, IGF-binding protein-1, IGF-binding protein-3, PGH, leptin and FFA. RESULTS:Exercise training in pregnancy had no impact on the pregnancy-related changes in the maternal IGF axis. Women in the exercise group experienced a 29% increase in leptin in late gestation (P=0·026 vs control) and a trend towards lower FFA (P=0·07 vs control). Late pregnancy changes in maternal leptin were inversely related to offspring birth weight (r= -0·24, P<0·05) and BMI (r= -0·25, P<0·05). CONCLUSIONS: An increase in leptin in exercising pregnant women may reflect subtle changes within the placenta in response to regular exercise and may contribute to the reduction in offspring size previously reported in this cohort.
RCT Entities:
CONTEXT & OBJECTIVE: A recent paper by our group reported that regular aerobic exercise during pregnancy led to lower foetal IGF-I and IGF-II concentrations and a modest reduction in offspring birth weight when compared with the offspring of nontraining control participants. Maternal hormonal alterations in response to exercise training may be associated with the regulation of nutrient availability for foetal growth through placental regulation of maternal metabolism. OBJECTIVE: To determine whether the reduction in offspring size was associated with changes in the maternal IGF axis [including placental growth hormone (PGH)], leptin and/or free fatty acids (FFA) in response to aerobic exercise training in the second half of pregnancy. DESIGN AND SETTING: A randomized, controlled trial of exercise in pregnancy. PATIENTS: Eighty-four healthy nulliparous women (mean±SD age 30±4 year, BMI 25·5±4 kg/m(2) ). MEASUREMENTS: Serum samples were drawn at 19 and 35 weeks gestation to determine serum IGF-I, IGF-II, IGF-binding protein-1, IGF-binding protein-3, PGH, leptin and FFA. RESULTS: Exercise training in pregnancy had no impact on the pregnancy-related changes in the maternal IGF axis. Women in the exercise group experienced a 29% increase in leptin in late gestation (P=0·026 vs control) and a trend towards lower FFA (P=0·07 vs control). Late pregnancy changes in maternal leptin were inversely related to offspring birth weight (r= -0·24, P<0·05) and BMI (r= -0·25, P<0·05). CONCLUSIONS: An increase in leptin in exercising pregnant women may reflect subtle changes within the placenta in response to regular exercise and may contribute to the reduction in offspring size previously reported in this cohort.
Authors: Josep C Jiménez-Chillarón; Mark J Nijland; António A Ascensão; Vilma A Sardão; José Magalhães; Michael J Hitchler; Frederick E Domann; Paulo J Oliveira Journal: Epigenetics Date: 2015-03-16 Impact factor: 4.528
Authors: Lauren E McCullough; Michelle A Mendez; Erline E Miller; Amy P Murtha; Susan K Murphy; Cathrine Hoyo Journal: Epigenetics Date: 2015-04-30 Impact factor: 4.528
Authors: Michael V Fedewa; Elizabeth D Hathaway; Christie L Ward-Ritacco; Tyler D Williams; Ward C Dobbs Journal: Sports Med Date: 2018-06 Impact factor: 11.136
Authors: Frederick Wasinski; Reury Frank Pereira Bacurau; Gabriel Rufino Estrela; Friederike Klempin; Aline Midori Arakaki; Rogerio Oliveira Batista; Fernando Francisco Pazello Mafra; Lucas Francisco Ribeiro do Nascimento; Meire Ioshie Hiyane; Lício Augusto Velloso; Niels Olsen Saraiva Câmara; Ronaldo Carvalho Araujo Journal: Nutr Metab (Lond) Date: 2015-12-18 Impact factor: 4.169