Literature DB >> 21198485

Can sugammadex save a patient in a simulated 'cannot intubate, cannot ventilate' situation?

M M A Bisschops1, C Holleman, J M Huitink.   

Abstract

Recent studies have shown that the use of high dose rocuronium followed by sugammadex provides a faster time to recovery from neuromuscular blockade following rapid sequence induction than suxamethonium. In a manikin-based 'cannot intubate, cannot ventilate' simulation, we studied the total time taken for anaesthetic teams to prepare and administer sugammadex from the time of their initial decision to use the drug. The mean (SD) total time to administration of sugammadex was 6.7 (1.5) min, following which a further 2.2 min (giving a total 8.9 min) should be allowed to achieve a train-of-four ratio of 0.9. Four (22%) teams gave the correct dose, 10 (56%) teams gave a dose that was lower than recommended, four (22%) teams gave a dose that was higher than recommended, six (33%) teams administered sugammadex in a single dose, and 12 (67%) teams gave multiple doses. Our simulation highlights that sugammadex might not have saved this patient in a 'cannot intubate, cannot ventilate' situation, and that difficulties and delays were encountered when identifying, preparing and administering the correct drug dose.
© 2010 The Authors. Journal compilation © 2010 The Association of Anaesthetists of Great Britain and Ireland.

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Year:  2010        PMID: 21198485     DOI: 10.1111/j.1365-2044.2010.06455.x

Source DB:  PubMed          Journal:  Anaesthesia        ISSN: 0003-2409            Impact factor:   6.955


  10 in total

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Journal:  Anaesthesist       Date:  2012-08       Impact factor: 1.041

Review 3.  Anaesthetic management of acute airway obstruction.

Authors:  Patrick Wong; Jolin Wong; May Un Sam Mok
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Review 4.  Airway management in patients undergoing emergency Cesarean section.

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Journal:  J Anesth       Date:  2015-05-28       Impact factor: 2.078

5.  Impact of Succinylcholine vs. Rocuronium on Apnea Duration for Rapid Sequence Induction: A Prospective Cohort Study.

Authors:  Lijun Tang; Xiao Zhao; Shitong Li; Lina Huang; Jinbao Li; Lianhua Chen; Shiwei Huang
Journal:  Front Med (Lausanne)       Date:  2022-02-09

6.  Canadian Airway Focus Group updated consensus-based recommendations for management of the difficult airway: part 2. Planning and implementing safe management of the patient with an anticipated difficult airway.

Authors:  J Adam Law; Laura V Duggan; Mathieu Asselin; Paul Baker; Edward Crosby; Andrew Downey; Orlando R Hung; George Kovacs; François Lemay; Rudiger Noppens; Matteo Parotto; Roanne Preston; Nick Sowers; Kathryn Sparrow; Timothy P Turkstra; David T Wong; Philip M Jones
Journal:  Can J Anaesth       Date:  2021-06-08       Impact factor: 5.063

Review 7.  Sugammadex as a reversal agent for neuromuscular block: an evidence-based review.

Authors:  Stefan Josef Schaller; Heidrun Fink
Journal:  Core Evid       Date:  2013-09-25

8.  Difficult Airway Society 2015 guidelines for management of unanticipated difficult intubation in adults.

Authors:  C Frerk; V S Mitchell; A F McNarry; C Mendonca; R Bhagrath; A Patel; E P O'Sullivan; N M Woodall; I Ahmad
Journal:  Br J Anaesth       Date:  2015-11-10       Impact factor: 9.166

9.  Peri-operative management of the obese surgical patient 2015: Association of Anaesthetists of Great Britain and Ireland Society for Obesity and Bariatric Anaesthesia.

Authors:  C E Nightingale; M P Margarson; E Shearer; J W Redman; D N Lucas; J M Cousins; W T A Fox; N J Kennedy; P J Venn; M Skues; D Gabbott; U Misra; J J Pandit; M T Popat; R Griffiths
Journal:  Anaesthesia       Date:  2015-05-07       Impact factor: 6.955

Review 10.  Sugammadex: Appropriate Use in the Context of Budgetary Constraints.

Authors:  Guy Cammu
Journal:  Curr Anesthesiol Rep       Date:  2018-03-20
  10 in total

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