OBJECTIVES: The purpose of this study was to evaluate the effect of Chamomilla recutita on the healing of ulcers in rats. STUDY DESIGN: A 5-mm wound was inflicted on the tongue of 36 rats. Treatment group animals were treated topically with 0.04 mL/day of chamomile ointment, whereas control group animals were not treated. Animals were sacrificed after 3, 7 or 10 days. Semi-quantitative analysis of the degree of inflammation, fibroblast count and wound size was performed, as well as histometric analysis of re-epithelialization and percentage of collagen fibers of the lesion. RESULTS: Animals treated with chamomile showed the best results regarding epithelialization and percentage of collagen fibers after 10 days. As expected, time had a statistically significant effect (p < 0.05) on fibroblast count, epithelialization, inflammation and wound size; animals sacrificed at 3 days showed the worst results. CONCLUSIONS: Chamomile stimulated re-epithelialization and the formation of collagen fibers after 10 days of treatment; it did not, however, influence inflammation or fibroblast count.
OBJECTIVES: The purpose of this study was to evaluate the effect of Chamomilla recutita on the healing of ulcers in rats. STUDY DESIGN: A 5-mm wound was inflicted on the tongue of 36 rats. Treatment group animals were treated topically with 0.04 mL/day of chamomile ointment, whereas control group animals were not treated. Animals were sacrificed after 3, 7 or 10 days. Semi-quantitative analysis of the degree of inflammation, fibroblast count and wound size was performed, as well as histometric analysis of re-epithelialization and percentage of collagen fibers of the lesion. RESULTS: Animals treated with chamomile showed the best results regarding epithelialization and percentage of collagen fibers after 10 days. As expected, time had a statistically significant effect (p < 0.05) on fibroblast count, epithelialization, inflammation and wound size; animals sacrificed at 3 days showed the worst results. CONCLUSIONS: Chamomile stimulated re-epithelialization and the formation of collagen fibers after 10 days of treatment; it did not, however, influence inflammation or fibroblast count.
Authors: Pia Lopez-Jornet; Fabio Camacho-Alonso; Francisco Gómez-Garcia; Francisco Molina Miñano; Xabier Cañas; Ana Serafín; Julian Castillo; Vicente Vicente-Ortega Journal: Int Wound J Date: 2012-11-09 Impact factor: 3.315
Authors: Manh Tin Ho; Hyun Sik Kang; Jung Sik Huh; Young Mee Kim; Yoongho Lim; Moonjae Cho Journal: Int J Mol Sci Date: 2014-07-23 Impact factor: 5.923
Authors: Hossein Salehi; Mohammad Mehrasa; Bijan Nasri-Nasrabadi; Mohsen Doostmohammadi; Reihaneh Seyedebrahimi; Navid Davari; Mohammad Rafienia; Mehdi E Hosseinabadi; Maria Agheb; Mansour Siavash Journal: J Res Med Sci Date: 2017-09-26 Impact factor: 1.852