Literature DB >> 21196412

Integrin-linked kinase 1: role in hormonal cancer progression.

Valerie Cortez1, Binoj C Nair, Dimple Chakravarty, Ratna K Vadlamudi.   

Abstract

Integrin-linked kinase 1 (ILK1) is a serine/threonine kinase that plays important roles in a variety of cellular functions including cell survival, migration and angiogenesis. ILK1 is normally expressed in numerous tissues and activated by growth factors, cytokines and hormones. Dysregulation of ILK1 expression or function is found in several hormonal tumors including breast, ovary and prostate. Emerging evidence suggests that ILK overexpression promotes cellular transformation, cell survival, epithelial mesenchymal transition (EMT), and metastasis of hormonal cancer cells while inhibition of ILK1 reduces tumor growth and progression. The recent development of ILK1 inhibitors has provided novel mechanisms for blocking ILK1 signaling to curb metastasis and therapy resistance of hormonal tumors. This review will focus on recent advances made towards understanding the role of ILK signaling axis in progression of hormonal cancer.

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Year:  2011        PMID： 21196412      PMCID： PMC3243948          DOI： 10.2741/s187

Source DB:  PubMed          Journal:  Front Biosci (Schol Ed)        ISSN： 1945-0516


  71 in total

1.  Integrin-linked kinase expression increases with prostate tumor grade.

Authors:  J R Graff; J A Deddens; B W Konicek; B M Colligan; B M Hurst; H W Carter; J H Carter
Journal:  Clin Cancer Res       Date:  2001-07       Impact factor: 12.531

2.  Extranuclear functions of ER impact invasive migration and metastasis by breast cancer cells.

Authors:  Dimple Chakravarty; Sujit S Nair; Bindu Santhamma; Binoj C Nair; Long Wang; Abhik Bandyopadhyay; Joseph K Agyin; Darrell Brann; Lu-Zhe Sun; I-Tien Yeh; Francis Y Lee; Rajeshwar Rao Tekmal; Rakesh Kumar; Ratna K Vadlamudi
Journal:  Cancer Res       Date:  2010-05-11       Impact factor: 12.701

3.  An inherent role of integrin-linked kinase-estrogen receptor alpha interaction in cell migration.

Authors:  Filippo Acconcia; Bramanandam Manavathi; Joseph Mascarenhas; Amjad H Talukder; Gordon Mills; Rakesh Kumar
Journal:  Cancer Res       Date:  2006-11-15       Impact factor: 12.701

4.  Integrin-linked kinase activity is associated with interleukin-1 alpha-induced progressive behavior of pancreatic cancer and poor patient survival.

Authors:  H Sawai; Y Okada; H Funahashi; Y Matsuo; H Takahashi; H Takeyama; T Manabe
Journal:  Oncogene       Date:  2006-01-16       Impact factor: 9.867

5.  Cell adhesion and the integrin-linked kinase regulate the LEF-1 and beta-catenin signaling pathways.

Authors:  A Novak; S C Hsu; C Leung-Hagesteijn; G Radeva; J Papkoff; R Montesano; C Roskelley; R Grosschedl; S Dedhar
Journal:  Proc Natl Acad Sci U S A       Date:  1998-04-14       Impact factor: 11.205

6.  Mammary epithelial-specific expression of the integrin-linked kinase (ILK) results in the induction of mammary gland hyperplasias and tumors in transgenic mice.

Authors:  D E White; R D Cardiff; S Dedhar; W J Muller
Journal:  Oncogene       Date:  2001-10-25       Impact factor: 9.867

7.  [Inhibitory effect of antisense oligonucleotide of integrin-linked kinase on cell proliferation of human epithelial ovarian cancer].

Authors:  Qi Li; Yan-Hua Zhang; Pei-Ling Li; Jun-Rui Pei
Journal:  Zhonghua Fu Chan Ke Za Zhi       Date:  2008-03

Review 8.  Integrin-linked kinase--essential roles in physiology and cancer biology.

Authors:  Paul C McDonald; Andrew B Fielding; Shoukat Dedhar
Journal:  J Cell Sci       Date:  2008-10-01       Impact factor: 5.285

9.  Integrin alphavbeta3 upregulates integrin-linked kinase expression in human ovarian cancer cells via enhancement of ILK gene transcription.

Authors:  Daniela Lössner; Claudia Abou-Ajram; Anke Benge; Marc Aumercier; Manfred Schmitt; Ute Reuning
Journal:  J Cell Physiol       Date:  2009-08       Impact factor: 6.384

10.  The prognostic significance of PELP1 expression in invasive breast cancer with emphasis on the ER-positive luminal-like subtype.

Authors:  Hany Onsy Habashy; Desmond G Powe; Emad A Rakha; Graham Ball; R Douglas Macmillan; Andrew R Green; Ian O Ellis
Journal:  Breast Cancer Res Treat       Date:  2009-06-03       Impact factor: 4.872
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  8 in total

1.  Differential proteomic analysis of pathway biomarkers in human breast cancer by integrated bioinformatics.

Authors:  Liu Fu-Jun; Jin Shao-Hua; Shen Xiao-Fang
Journal:  Oncol Lett       Date:  2012-08-24       Impact factor: 2.967

2.  MicroRNA-542-3p Suppresses Tumor Cell Invasion via Targeting AKT Pathway in Human Astrocytoma.

Authors:  Junchao Cai; JingJing Zhao; Nu Zhang; Xiaonan Xu; Rong Li; Yang Yi; Lishan Fang; Le Zhang; Mengfeng Li; Jueheng Wu; Heng Zhang
Journal:  J Biol Chem       Date:  2015-08-18       Impact factor: 5.157

3.  ILK and PRDX1 are prognostic markers in squamous cell/adenosquamous carcinomas and adenocarcinoma of gallbladder.

Authors:  Jinghe Li; Zhu-Lin Yang; Xuebao Ren; Qiong Zou; Yuan Yuan; Lufeng Liang; Meigui Chen; Senlin Chen
Journal:  Tumour Biol       Date:  2012-10-13

4.  Comparison of ILK and ERP29 expressions in benign and malignant pancreatic lesions and their clinicopathological significances in pancreatic ductal adenocarcinomas.

Authors:  K Zhang; H Yao; Z Yang; D Li; L Yang; Q Zou; Y Yuan; X Miao
Journal:  Clin Transl Oncol       Date:  2016-02-18       Impact factor: 3.405

5.  Effect of integrin‑linked kinase gene silencing on microRNA expression in ovarian cancer.

Authors:  Dandan Yuan; Yilei Zhao; Yang Wang; Jianhua Che; Wenhua Tan; Yuxia Jin; Fei Wang; Peiliang Li; Shuyan Fu; Qian Liu; Wenliang Zhu
Journal:  Mol Med Rep       Date:  2017-09-19       Impact factor: 2.952

6.  Downregulation of PARVA promotes metastasis by modulating integrin-linked kinase activity and regulating MAPK/ERK and MLC2 signaling in prostate cancer.

Authors:  Cong Huang; Qi Shen; Gang Song; Shiming He; Liqun Zhou
Journal:  Transl Androl Urol       Date:  2021-02

Review 7.  Integrin-linked kinase (ILK): the known vs. the unknown and perspectives.

Authors:  Agata Górska; Antonina Joanna Mazur
Journal:  Cell Mol Life Sci       Date:  2022-01-28       Impact factor: 9.261

8.  Differential expressions of integrin-linked kinase, β-parvin and cofilin 1 in high-fat diet induced prostate cancer progression in a transgenic mouse model.

Authors:  Meng-Bo Hu; Ji-Meng Hu; Li-Ren Jiang; Tian Yang; Wen-Hui Zhu; Yun Hu; Xiao-Bo Wu; Hao-Wen Jiang; Qiang Ding
Journal:  Oncol Lett       Date:  2018-08-07       Impact factor: 2.967
  8 in total

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