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Literature DB >> 21196410

RAGE and its ligands in bone metabolism.

Abstract

The receptor for advanced glycation end products (RAGE), a member of the immunoglobulin super-family transmembrane proteins, has multiple ligands, thus, is implicated in the pathogenesis of various diseases, including diabetic complications, neurodegenerative disorders, and inflammatory responses. Its function in normal physiology is beginning to be defined, and recent studies have pointed to an important role for RAGE and its ligands (e.g., HMGB1 (high mobility group box 1)) in innate immune response. In addition, RAGE and its ligands are also implicated in osteoclast activation and bone remodeling. Understanding how RAGE and its ligands regulate bone remodeling may provide insight into the pathogenesis of diabetes and chronic inflammation associated bone loss. Recent progress relevant to the functions of RAGE and its ligands in bone remodeling is discussed in this review.

Entities: Chemical

Mesh：

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Year: 2011 PMID： 21196410 PMCID： PMC3815642 DOI： 10.2741/s185

Source DB: PubMed Journal: Front Biosci (Schol Ed) ISSN： 1945-0516

73 in total

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Authors: D J Selkoe
Journal: Physiol Rev Date: 2001-04 Impact factor: 37.312

Review 2. Osteoclast differentiation and activation.

Authors: William J Boyle; W Scott Simonet; David L Lacey
Journal: Nature Date: 2003-05-15 Impact factor: 49.962

Review 3. The role of HMGB1 in the pathogenesis of rheumatic disease.

Authors: Ulf Andersson; Helena Erlandsson Harris
Journal: Biochim Biophys Acta Date: 2010 Jan-Feb

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Authors: T Miyata; R Kawai; S Taketomi; S M Sprague
Journal: Nephrol Dial Transplant Date: 1996 Impact factor: 5.992

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Journal: Cesk Patol Date: 2008-07

Review 6. Endogenous alpha-oxoaldehydes and formation of protein and nucleotide advanced glycation endproducts in tissue damage.

Authors: Paul J Thornalley
Journal: Novartis Found Symp Date: 2007

7. A role for advanced glycation end products in diminished bone healing in type 1 diabetes.

Authors: Ronaldo B Santana; Lei Xu; Hermik Babakhanlou Chase; Salomon Amar; Dana T Graves; Philip C Trackman
Journal: Diabetes Date: 2003-06 Impact factor: 9.461

8. HMGB1 is a bone-active cytokine.

Authors: Jieping Yang; Rita Shah; Alexander G Robling; Evan Templeton; Huan Yang; Kevin J Tracey; Joseph P Bidwell
Journal: J Cell Physiol Date: 2008-03 Impact factor: 6.384

Review 9. Dietary AGEs and ALEs and risk to human health by their interaction with the receptor for advanced glycation endproducts (RAGE)--an introduction.

Authors: Paul J Thornalley
Journal: Mol Nutr Food Res Date: 2007-09 Impact factor: 5.914

10. Oxaliplatin retains HMGB1 intranuclearly and ameliorates collagen type II-induced arthritis.

Authors: Therese Ostberg; Heidi Wähämaa; Karin Palmblad; Norimasa Ito; Pernilla Stridh; Maria Shoshan; Michael T Lotze; Helena Erlandsson Harris; Ulf Andersson
Journal: Arthritis Res Ther Date: 2008-01-07 Impact factor: 5.156

16 in total

1. Innate immunity sensors participating in pathophysiology of joint diseases: a brief overview.

Authors: Jiri Gallo; Milan Raska; Yrjo T Konttinen; Christophe Nich; Stuart B Goodman
Journal: J Long Term Eff Med Implants Date: 2014

2. Short-term pharmacologic RAGE inhibition differentially affects bone and skeletal muscle in middle-aged mice.

Authors: Hannah M Davis; Alyson L Essex; Sinai Valdez; Padmini J Deosthale; Mohammad W Aref; Matthew R Allen; Andrea Bonetto; Lilian I Plotkin
Journal: Bone Date: 2019-04-24 Impact factor: 4.398

3. Increase of novel biomarkers for oxidative stress in patients with plasma cell disorders and in multiple myeloma patients with bone lesions.

Authors: Sebastiano Gangemi; Alessandro Allegra; Andrea Alonci; Mariateresa Cristani; Sabina Russo; Antonio Speciale; Giuseppa Penna; Giovanna Spatari; Antonino Cannavò; Giacomo Bellomo; Caterina Musolino
Journal: Inflamm Res Date: 2012-06-07 Impact factor: 4.575

Review 4. RAGE Signaling in Skeletal Biology.

Authors: Lilian I Plotkin; Alyson L Essex; Hannah M Davis
Journal: Curr Osteoporos Rep Date: 2019-02 Impact factor: 5.096

Review 5. Ousting RAGE in melanoma: A viable therapeutic target?

Authors: Deeba N Syed; Ahmed Aljohani; Durdana Waseem; Hasan Mukhtar
Journal: Semin Cancer Biol Date: 2017-10-24 Impact factor: 15.707

6. Osteoblasts remotely supply lung tumors with cancer-promoting SiglecF^high neutrophils.

Authors: Camilla Engblom; Christina Pfirschke; Rapolas Zilionis; Janaina Da Silva Martins; Stijn A Bos; Gabriel Courties; Steffen Rickelt; Nicolas Severe; Ninib Baryawno; Julien Faget; Virginia Savova; David Zemmour; Jaclyn Kline; Marie Siwicki; Christopher Garris; Ferdinando Pucci; Hsin-Wei Liao; Yi-Jang Lin; Andita Newton; Omar K Yaghi; Yoshiko Iwamoto; Benoit Tricot; Gregory R Wojtkiewicz; Matthias Nahrendorf; Virna Cortez-Retamozo; Etienne Meylan; Richard O Hynes; Marie Demay; Allon Klein; Miriam A Bredella; David T Scadden; Ralph Weissleder; Mikael J Pittet
Journal: Science Date: 2017-12-01 Impact factor: 47.728

7. High mobility group box 1 protein regulates osteoclastogenesis through direct actions on osteocytes and osteoclasts in vitro.

Authors: Hannah M Davis; Sinai Valdez; Leland Gomez; Peter Malicky; Fletcher A White; Mark A Subler; Jolene J Windle; Joseph P Bidwell; Angela Bruzzaniti; Lilian I Plotkin
Journal: J Cell Biochem Date: 2019-05-20 Impact factor: 4.429

8. Molecular signaling of the HMGB1/RAGE axis contributes to cholesteatoma pathogenesis.

Authors: Miroslaw J Szczepanski; Michal Luczak; Ewa Olszewska; Marta Molinska-Glura; Mariola Zagor; Antoni Krzeski; Henryk Skarzynski; Jan Misiak; Karolina Dzaman; Mikolaj Bilusiak; Tomasz Kopec; Malgorzata Leszczynska; Henryk Witmanowski; Theresa L Whiteside
Journal: J Mol Med (Berl) Date: 2014-11-12 Impact factor: 4.599

9. HMGB1 Induces Secretion of Matrix Vesicles by Macrophages to Enhance Ectopic Mineralization.

Authors: Qiang Chen; Jun-Jie Bei; Chuan Liu; Shi-Bin Feng; Wei-Bo Zhao; Zhou Zhou; Zheng-Ping Yu; Xiao-Jun Du; Hou-Yuan Hu
Journal: PLoS One Date: 2016-05-31 Impact factor: 3.240

10. Discovery of circulating proteins associated to knee radiographic osteoarthritis.

Authors: Lucía Lourido; Burcu Ayoglu; Juan Fernández-Tajes; Natividad Oreiro; Frauke Henjes; Cecilia Hellström; Jochen M Schwenk; Cristina Ruiz-Romero; Peter Nilsson; Francisco J Blanco
Journal: Sci Rep Date: 2017-03-09 Impact factor: 4.379