Literature DB >> 21196161

TGF-beta-dependent and -independent roles of STRAP in cancer.

Jennifer Elisabeth Reiner1, Pran K Datta.   

Abstract

The serine-threonine kinase receptor-associated protein (STRAP) was initially identified as a putative inhibitor of the canonical TGF-beta signaling pathway. Because the Smad-dependent TGF-beta pathway negatively regulates cellular growth, early functional studies suggested that STRAP behaves as an oncogene. Indeed, a correlation between STRAP overexpression and various cancers has been identified. With the emergence of new studies on the biological function of STRAP, it is becoming clear that STRAP regulates several distinct cellular processes and modulates multiple signaling pathways. While STRAP itself does not possess enzymatic activity, it appears that STRAP influences biological processes through associations with cellular proteins. In this review, we will describe the TGF-beta-dependent and -independent functions of STRAP and provide a context for the significance of STRAP activity in the development of cancer.

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Year:  2011        PMID： 21196161      PMCID： PMC4281466          DOI： 10.2741/3678

Source DB:  PubMed          Journal:  Front Biosci (Landmark Ed)        ISSN： 2768-6698


  82 in total

1.  TGF beta-mediated RhoA expression is necessary for epithelial-mesenchymal transition in the embryonic chick heart.

Authors:  André Luiz P Tavares; Melania E Mercado-Pimentel; Raymond B Runyan; Gregory T Kitten
Journal:  Dev Dyn       Date:  2006-06       Impact factor: 3.780

2.  A WD-domain protein that is associated with and phosphorylated by the type II TGF-beta receptor.

Authors:  R H Chen; P J Miettinen; E M Maruoka; L Choy; R Derynck
Journal:  Nature       Date:  1995-10-12       Impact factor: 49.962

3.  Ewing sarcoma 11;22 translocation produces a chimeric transcription factor that requires the DNA-binding domain encoded by FLI1 for transformation.

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Journal:  Proc Natl Acad Sci U S A       Date:  1993-06-15       Impact factor: 11.205

4.  Reduced tumor incidence, metastatic potential, and cytokine responsiveness of nm23-transfected melanoma cells.

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Journal:  Cell       Date:  1991-04-05       Impact factor: 41.582

5.  STRAP and Smad7 synergize in the inhibition of transforming growth factor beta signaling.

Authors:  P K Datta; H L Moses
Journal:  Mol Cell Biol       Date:  2000-05       Impact factor: 4.272

6.  ASK1 and ASK2 differentially regulate the counteracting roles of apoptosis and inflammation in tumorigenesis.

Authors:  Takayuki Iriyama; Kohsuke Takeda; Hiromi Nakamura; Yoshifumi Morimoto; Takumi Kuroiwa; Junya Mizukami; Tsuyoshi Umeda; Takuya Noguchi; Isao Naguro; Hideki Nishitoh; Kaoru Saegusa; Kei Tobiume; Toshiki Homma; Yutaka Shimada; Hitoshi Tsuda; Satoshi Aiko; Issei Imoto; Johji Inazawa; Kazuhiro Chida; Yoshimasa Kamei; Shiro Kozuma; Yuji Taketani; Atsushi Matsuzawa; Hidenori Ichijo
Journal:  EMBO J       Date:  2009-02-12       Impact factor: 11.598

7.  EWS/Fli-1 chimeric protein is a transcriptional activator.

Authors:  T Ohno; V N Rao; E S Reddy
Journal:  Cancer Res       Date:  1993-12-15       Impact factor: 12.701

8.  A critical role of tropomyosins in TGF-beta regulation of the actin cytoskeleton and cell motility in epithelial cells.

Authors:  Andrei V Bakin; Alfiya Safina; Cammie Rinehart; Cecilia Daroqui; Huferesh Darbary; David M Helfman
Journal:  Mol Biol Cell       Date:  2004-08-18       Impact factor: 4.138

Review 9.  Smad-dependent and Smad-independent pathways in TGF-beta family signalling.

Authors:  Rik Derynck; Ying E Zhang
Journal:  Nature       Date:  2003-10-09       Impact factor: 49.962

10.  New anti-cancer role for PDK1 inhibitors: preventing resistance to tamoxifen.

Authors:  Christian Peifer; Dario R Alessi
Journal:  Biochem J       Date:  2009-01-01       Impact factor: 3.857
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  14 in total

1.  STRAP regulates c-Jun ubiquitin-mediated proteolysis and cellular proliferation.

Authors:  Jennifer Reiner; Fei Ye; Nilesh D Kashikar; Pran K Datta
Journal:  Biochem Biophys Res Commun       Date:  2011-03-21       Impact factor: 3.575

2.  STRAP: A Bridge Between Mutant APC and Wnt/ß-Catenin Signaling in Intestinal Cancer.

Authors:  Lopa Mishra
Journal:  Gastroenterology       Date:  2021-10-19       Impact factor: 22.682

3.  Regulation of Na,K-ATPase β1-subunit in TGF-β2-mediated epithelial-to-mesenchymal transition in human retinal pigmented epithelial cells.

Authors:  Sridevi Mony; Seung Joon Lee; Jeffrey F Harper; Sonali P Barwe; Sigrid A Langhans
Journal:  Exp Eye Res       Date:  2013-06-28       Impact factor: 3.467

4.  Phosphorylation of ΔNp63α via a novel TGFβ/ALK5 signaling mechanism mediates the anti-clonogenic effects of TGFβ.

Authors:  Pratima Cherukuri; Andrew J DeCastro; Amanda L Balboni; Sondra L Downey; Jennifer Y Liu; Justine A Hutchinson; James DiRenzo
Journal:  PLoS One       Date:  2012-11-16       Impact factor: 3.240

5.  Serine-threonine Kinase Receptor-Associated Protein is a Critical Mediator of APC Mutation-Induced Intestinal Tumorigenesis Through a Feed-Forward Mechanism.

Authors:  Trung Vu; Arunima Datta; Carolyn Banister; Lin Jin; Guandou Yuan; Temesgen Samuel; Sejong Bae; Isam-Eldin Eltoum; Upender Manne; Bixiang Zhang; Robert S Welner; Kasturi Mitra; Phillip Buckhaults; Pran K Datta
Journal:  Gastroenterology       Date:  2021-09-11       Impact factor: 33.883

6.  Serine-Threonine Kinase Receptor Associate Protein (STRAP) confers an aggressive phenotype in neuroblastoma via regulation of Focal Adhesion Kinase (FAK).

Authors:  Laura V Bownes; Raoud Marayati; Colin H Quinn; Sara C Hutchins; Jerry E Stewart; Joshua C Anderson; Christopher D Willey; Pran K Datta; Elizabeth A Beierle
Journal:  J Pediatr Surg       Date:  2022-02-14       Impact factor: 2.549

7.  Proteomic analysis of proton beam irradiated human melanoma cells.

Authors:  Sylwia Kedracka-Krok; Urszula Jankowska; Martyna Elas; Urszula Sowa; Jan Swakon; Agnieszka Cierniak; Pawel Olko; Bozena Romanowska-Dixon; Krystyna Urbanska
Journal:  PLoS One       Date:  2014-01-02       Impact factor: 3.240

8.  RNA-seq analysis of impact of PNN on gene expression and alternative splicing in corneal epithelial cells.

Authors:  Debra Akin; Jeremy R B Newman; Lauren M McIntyre; Stephen P Sugrue
Journal:  Mol Vis       Date:  2016-01-16       Impact factor: 2.367

9.  Serine-Threonine Kinase Receptor-Associated Protein (STRAP) Knockout Decreases the Malignant Phenotype in Neuroblastoma Cell Lines.

Authors:  Laura V Bownes; Adele P Williams; Raoud Marayati; Colin H Quinn; Sara C Hutchins; Jerry E Stewart; Trung Vu; Juliet L Easlick; Elizabeth Mroczek-Musulman; David K Crossman; Joshua C Anderson; Christopher D Willey; Pran K Datta; Elizabeth A Beierle
Journal:  Cancers (Basel)       Date:  2021-06-26       Impact factor: 6.639

Review 10.  Pharmacology and rationale for imatinib in the treatment of scleroderma.

Authors:  Pia Moinzadeh; Nicolas Hunzelmann; Thomas Krieg
Journal:  J Exp Pharmacol       Date:  2013-04-04
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