BACKGROUND: The authors presented their experience in regenerative surgery of post-traumatic lower extremity ulcers, evaluating the effects related to the use of Enhanced Stromal Vascular Fraction (e-SVF) and Fat Grafting with Platelet rich Plasma (PRP). The authors compared the results of two control groups. METHOD: The analysis involved 20 patients aged between 23 to 62 years affected by post-traumatic lower extremity ulcers. 10 patients managed with e-SVF and 10 patients managed with Fat grafting+PRP in the Plastic and Reconstructive Surgery Department at "Tor Vergata" University Rome. Patients in the first control group (n=10), were treated only with curettage and application of hyaluronic acid in the bed of ulcers. Patients in the second control group (n=10), were treated only with PRP. RESULTS: The authors showed that wounds treated with e-SVF healed better than those treated with hyaluronic acid. In fact, after 9.7 weeks, patients treated with e-SVF underwent 97.9% ± 1.5% reepithelialisation compared to 87.8% ± 4.4% of the first control group (only hyaluronic acid; p<0.05). Patients treated with PRP and fat grafting also showed an improvement in reepithelialisation; in fact after 9.7 weeks, they underwent a 97.8% ± 1.5% reepithelialisation compared to 89.1% ± 3.8% of the second control group (only PRP; p<0.05). As reported e-SVF and PRP mixed with fat grafting were the two treatments evidencing improvement in the healing of patients post-traumatic extremity ulcers. CONCLUSIONS: The results obtained proved the efficacy of these treatments, and the satisfaction of the patients confirmed the quality of the results.
BACKGROUND: The authors presented their experience in regenerative surgery of post-traumatic lower extremity ulcers, evaluating the effects related to the use of Enhanced Stromal Vascular Fraction (e-SVF) and Fat Grafting with Platelet rich Plasma (PRP). The authors compared the results of two control groups. METHOD: The analysis involved 20 patients aged between 23 to 62 years affected by post-traumatic lower extremity ulcers. 10 patients managed with e-SVF and 10 patients managed with Fat grafting+PRP in the Plastic and Reconstructive Surgery Department at "Tor Vergata" University Rome. Patients in the first control group (n=10), were treated only with curettage and application of hyaluronic acid in the bed of ulcers. Patients in the second control group (n=10), were treated only with PRP. RESULTS: The authors showed that wounds treated with e-SVF healed better than those treated with hyaluronic acid. In fact, after 9.7 weeks, patients treated with e-SVF underwent 97.9% ± 1.5% reepithelialisation compared to 87.8% ± 4.4% of the first control group (only hyaluronic acid; p<0.05). Patients treated with PRP and fat grafting also showed an improvement in reepithelialisation; in fact after 9.7 weeks, they underwent a 97.8% ± 1.5% reepithelialisation compared to 89.1% ± 3.8% of the second control group (only PRP; p<0.05). As reported e-SVF and PRP mixed with fat grafting were the two treatments evidencing improvement in the healing of patients post-traumatic extremity ulcers. CONCLUSIONS: The results obtained proved the efficacy of these treatments, and the satisfaction of the patients confirmed the quality of the results.
Authors: John K Fraser; Kevin C Hicok; Rob Shanahan; Min Zhu; Scott Miller; Douglas M Arm Journal: Adv Wound Care (New Rochelle) Date: 2014-01-01 Impact factor: 4.730
Authors: Pietro Gentile; Augusto Orlandi; Maria Giovanna Scioli; Camilla Di Pasquali; Ilaria Bocchini; Valerio Cervelli Journal: Stem Cells Transl Med Date: 2012-02-22 Impact factor: 6.940
Authors: Ivan Martin; Helen Baldomero; Chiara Bocelli-Tyndall; Maximilian Y Emmert; Simon P Hoerstrup; Hilary Ireland; Jakob Passweg; Alan Tyndall Journal: Tissue Eng Part A Date: 2013-11-08 Impact factor: 3.845
Authors: Valerio Cervelli; Maria G Scioli; Pietro Gentile; Elena Doldo; Elena Bonanno; Luigi G Spagnoli; Augusto Orlandi Journal: Stem Cells Transl Med Date: 2012-03-07 Impact factor: 6.940