| Literature DB >> 21195617 |
Yong-Kang Zhang1, Jacob J Plattner, Yvonne R Freund, Eric E Easom, Yasheen Zhou, Jiri Gut, Philip J Rosenthal, David Waterson, Francisco-Javier Gamo, Inigo Angulo-Barturen, Min Ge, Zhiya Li, Lingchao Li, Yong Jian, Han Cui, Hailong Wang, Jian Yang.
Abstract
A series of boron-containing benzoxaborole compounds was designed and synthesized for a structure-activity relationship investigation surrounding 7-(HOOCCH(2)CH(2))-1,3-dihydro-1-hydroxy-2,1-benzoxaborole (1) with the goal of discovering a new antimalarial treatment. Compound 1 demonstrates the best potency (IC(50)=26nM) against Plasmodium falciparum and has good drug-like properties, with low molecular weight (206.00), low ClogP (0.86) and high water solubility (750μg/mL at pH 7). Copyright ÂEntities:
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Year: 2010 PMID： 21195617 DOI： 10.1016/j.bmcl.2010.12.034
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823