UNLABELLED: We previously reported bronchial circulation contributes to pulmonary edema and increases shunt fraction following smoke inhalation, and bronchial blood flow significantly increases in inhalation injury. We hypothesized reduction of bronchial blood flow reduces exudation to the airway and ameliorates lung injury from combined burn and smoke insults (B&S injury). METHOD: Merino ewes (n=28) randomly divided into three groups: (1) bronchial artery ligated and injured (injury+ligation group); (2) bronchial artery left intact and injured (injury+no ligation group); (3) bronchial artery ligated but not injured (no injury+ligation group) were subjected to a flame burn and inhalation injury under halothane anesthesia. Parameters were analyzed using Scheffe's post hoc test (P<0.05). All Groups were resuscitated with Ringer lactate solution and placed on a ventilator for 48h. RESULTS: Pulmonary gas exchange (PaO(2)/FiO(2)) improved in injury+ligation group. Further, obstruction score, an index of airway cast formation, significantly changed between injury+no ligation group compared to both ligation groups. CONCLUSION: Bronchial circulation plays a significant role in lung injury after B&S injury, and reduction of bronchial blood flow by bronchial artery ligation reduces bronchial exudates, resulting in improved gas exchange.
UNLABELLED: We previously reported bronchial circulation contributes to pulmonary edema and increases shunt fraction following smoke inhalation, and bronchial blood flow significantly increases in inhalation injury. We hypothesized reduction of bronchial blood flow reduces exudation to the airway and ameliorates lung injury from combined burn and smoke insults (B&S injury). METHOD: Merino ewes (n=28) randomly divided into three groups: (1) bronchial artery ligated and injured (injury+ligation group); (2) bronchial artery left intact and injured (injury+no ligation group); (3) bronchial artery ligated but not injured (no injury+ligation group) were subjected to a flame burn and inhalation injury under halothane anesthesia. Parameters were analyzed using Scheffe's post hoc test (P<0.05). All Groups were resuscitated with Ringer lactate solution and placed on a ventilator for 48h. RESULTS: Pulmonary gas exchange (PaO(2)/FiO(2)) improved in injury+ligation group. Further, obstruction score, an index of airway cast formation, significantly changed between injury+no ligation group compared to both ligation groups. CONCLUSION: Bronchial circulation plays a significant role in lung injury after B&S injury, and reduction of bronchial blood flow by bronchial artery ligation reduces bronchial exudates, resulting in improved gas exchange.
Authors: Kazunori Murakami; Roy McGuire; Robert A Cox; Jeffrey M Jodoin; Frank C Schmalstieg; Lillian D Traber; Hal K Hawkins; David N Herndon; Daniel L Traber Journal: Crit Care Med Date: 2003-02 Impact factor: 7.598
Authors: Robert A Cox; Ann S Burke; Kazutaka Soejima; Kazunori Murakami; Jiro Katahira; Lillian D Traber; David N Herndon; Frank C Schmalstieg; Daniel L Traber; Hal K Hawkins Journal: Am J Respir Cell Mol Biol Date: 2003-09 Impact factor: 6.914
Authors: Perenlei Enkhbaatar; Kazunori Murakami; Robert Cox; Martin Westphal; Naoki Morita; Kimberly Brantley; Ann Burke; Hal Hawkins; Frank Schmalstieg; Lillian Traber; David Herndon; Daniel Traber Journal: Shock Date: 2004-07 Impact factor: 3.454
Authors: Perenlei Enkhbaatar; Kazunori Murakami; Katsumi Shimoda; Akio Mizutani; Roy McGuire; Frank Schmalstieg; Robert Cox; Hal Hawkins; Jeffery Jodoin; Steve Lee; Lillian Traber; David Herndon; Daniel Traber Journal: Am J Physiol Regul Integr Comp Physiol Date: 2003-05-22 Impact factor: 3.619
Authors: Guillermo Foncerrada; Derek M Culnan; Karel D Capek; Sagrario González-Trejo; Janos Cambiaso-Daniel; Lee C Woodson; David N Herndon; Celeste C Finnerty; Jong O Lee Journal: Ann Plast Surg Date: 2018-03 Impact factor: 1.539
Authors: Guillermo Foncerrada; Francisco Lima; Robert P Clayton; Ronald P Mlcak; Perenlei Enkhbaatar; David N Herndon; Oscar E Suman Journal: J Burn Care Res Date: 2017 Nov/Dec Impact factor: 1.845
Authors: Saul Chemonges; Kiran Shekar; John-Paul Tung; Kimble R Dunster; Sara Diab; David Platts; Ryan P Watts; Shaun D Gregory; Samuel Foley; Gabriela Simonova; Charles McDonald; Rylan Hayes; Judith Bellpart; Daniel Timms; Michelle Chew; Yoke L Fung; Michael Toon; Marc O Maybauer; John F Fraser Journal: Biomed Res Int Date: 2014-03-25 Impact factor: 3.411
Authors: Perenlei Enkhbaatar; Basil A Pruitt; Oscar Suman; Ronald Mlcak; Steven E Wolf; Hiroyuki Sakurai; David N Herndon Journal: Lancet Date: 2016-10-01 Impact factor: 79.321
Authors: Patrick F Walker; Michelle F Buehner; Leslie A Wood; Nathan L Boyer; Ian R Driscoll; Jonathan B Lundy; Leopoldo C Cancio; Kevin K Chung Journal: Crit Care Date: 2015-10-28 Impact factor: 9.097